摘要 : Aim: Tuberculosis (TB) is one of the world's deadliest chronic infectious diseases caused mainly by Mycobacterium tuberculosis (MTB). Many nitrofuran derivatives were found to possess promising anti-TB potential and have been wide... 展开 Aim: Tuberculosis (TB) is one of the world's deadliest chronic infectious diseases caused mainly by Mycobacterium tuberculosis (MTB). Many nitrofuran derivatives were found to possess promising anti-TB potential and have been widely studied. In our previous study, we discovered diazaspiro-nitrofuran IMB1701-1702 as potent anti-TB agents. Methodology: We report herein a series of nitrofuranyl methyl N -heterocycles based on IMB1701-1702. Results reveal that most of them show potent activity (minimum inhibitory concentration: 7h without cytotoxicity, has the same minimum inhibitory concentration value of ≤0.016?μg/ml as PBTZ169 against both MTB H37Rv strain and two clinically isolated multidrug-resistant MTB strains. Conclusion: The newly designed compound 7h might be a promising anti-TB candidate.Graphical abstract. 收起