摘要 : It is well known that the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are involved in learning and memory. Specialists of Zakusov Research Institute of Pharmacology designed and synthesized... 展开 It is well known that the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are involved in learning and memory. Specialists of Zakusov Research Institute of Pharmacology designed and synthesized dimeric dipeptide mimetics of the 1(st) (GK-6) and 4(th) (GK-2) NGF loops and the 1(st) (GSB-214), 2(nd) (GTS-201), and 4(th) (GSB-106) BDNF loops that in vitro activated TrkA or TrkB receptors, respectively. Differences in the activation of PI3K/AKT, MAPK/ERK, and PLC-gamma 1 were recorded during incubation in HT-22 cell culture for 5 - 180 min. This work was aimed to study the mnemotropic activity of the original NGF and BDNF mimetics in the new-object recognition test in rats. The dipeptides were administered once intraperitoneally. It was found that GK-2 (0.5 and 1.0 mg/kg) and GSB-214 (0.1 and 1.0 mg/kg), activating PI3K/AKT and PLC-gamma 1 signaling pathways without affecting MAPK/ERK, statistically significantly improved long-term memory. Dipeptides GK-2 and GSB-214 seem promising for further development as drugs for correcting memory impairments. 收起