摘要 :
The cumulative physiologic effects of psychological, physical and surgical stress result in hypothalamic-pituitary-adrenal (HPA) mediated peripheral vasoconstriction and elevated serum cortisol levels, both of which have been impl...
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The cumulative physiologic effects of psychological, physical and surgical stress result in hypothalamic-pituitary-adrenal (HPA) mediated peripheral vasoconstriction and elevated serum cortisol levels, both of which have been implicated in wound healing. The purpose of this study was to describe the affects of both preoperative and postoperative psychological stress and minor and moderate surgical stress on wound healing in the hope of gaining insight into what characteristics within individuals are most likely to equate with efficient would healing.
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摘要 :
During this quarter we conducted cell-binding experiments and assays for mitogenesis and chemotaxis on the four peptides mentioned above. The results are shown in Tables 1 through 3. None of these peptides showed any cell binding ...
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During this quarter we conducted cell-binding experiments and assays for mitogenesis and chemotaxis on the four peptides mentioned above. The results are shown in Tables 1 through 3. None of these peptides showed any cell binding or mitogenesis. PDGF A (77-88) showed chemotaxis. We are repeating the assay for this peptide.
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摘要 :
The hypothesis of these studies is that genetic processes that lead to the variations in both structural and material properties of bone development will be recapitulated in the developmental mechanisms that control the bone quali...
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The hypothesis of these studies is that genetic processes that lead to the variations in both structural and material properties of bone development will be recapitulated in the developmental mechanisms that control the bone quality during fracture healing. Two goals were set out in this proposal to test this hypothesis. the First was to determine how variations in basic bone quality in the three in bred strains of mice were expressed during fracture healing. MicroCT and mechanical testing of day 21 and 35 fracture calluses demonstrated that each strain recapitulated their variations in geometric and material properties during fracture healing. Furthermore, variations in bone quality differentially effected the rates of healing (i.e. there are genetic variations slow versus fast bone healing). The second goal was directed at identifying the underlying biological processes that lead to genetic variation, which effect both bone quality and rates of fracture healing which recapitulate differences seen in original bone growth. Large scale transcriptional profiling initiated during the tenure of this grant is ongoing to further define genetic variability in fracture healing.
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