摘要 :
Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis.These reactions are attractive because of they allow for inherently efficient construction of organic buil...
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Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis.These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates.Of these processes,C-H arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry.We can synthesis the target compound which is difficult to be obtained by traditional method via C-H activiation in an atom-economic manner.It is an economical and efficient approach to synthesis a complex compound by direct functionalization of C-H bond.
Herein,the studies of palladium catalyzed o-C-H arylation ofαt-phenylalanine derivatives and therefore produce a series of arene substituted compounds was described.The main content is Pd catalyzed aromatic C-H arylation ofα-phenylalanine derivates directed by pyridineamide as a targeting group.
In addition to being the subunit of peptides and proteins,amino acids are employed in total synthesis and ligand elaboration as chiral building blocks,chiral ligands,or chiral catalysts.Because of their broad spectrum of applications and the limited number of amino acids genetically encoded,there is an urgent for developing new methodologies for the chemical modifications of amino acids and peptides directly.This paper aims to study Pd catalyzed C-H arylation of the amino acid derivates assisted by pyridineamide and therefore pyridineamide directed C-H arylation ofα-phenylalanine for synthesis of unnatural amino acids was described.
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摘要 :
该论文首次使用氮化钼为催化剂对具有重要工业应用背景的乙炔和丁二烯加氢反应进行了研究,结合程序升温表面反应(TPSR)、原位红外(IR in situ)等表征结果发现氮化钼在低温具有丁二烯选择加氢至丁烯的性能(25℃转化率为70%,100℃时转化率为100%,1-丁烯...
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该论文首次使用氮化钼为催化剂对具有重要工业应用背景的乙炔和丁二烯加氢反应进行了研究,结合程序升温表面反应(TPSR)、原位红外(IR in situ)等表征结果发现氮化钼在低温具有丁二烯选择加氢至丁烯的性能(25℃转化率为70%,100℃时转化率为100%,1-丁烯的选择性可达95%以上),同时发现反应中存在自中毒现象.
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