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Brucellosis has been reported mainly among pregnant women, and it may lead to spontaneous abortion, intrauterine fetal death, or delivery of an infected neonate. Transmission through breast milk has also been described, but congen...
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Brucellosis has been reported mainly among pregnant women, and it may lead to spontaneous abortion, intrauterine fetal death, or delivery of an infected neonate. Transmission through breast milk has also been described, but congenital cases are not commonly reported. We present the clinical findings, laboratory studies, treatment, and final outcome of a late prenatal transmission from a mother to her term infant of Brucella melitensis biovar 1. Because the maternal disease was undetected due to lack of clinical suspicion, diagnosis was made possible only by the results of infant blood cultures. Differential diagnosis of fever of unknown origin (FUO) misdiagnosed could result, as in our case, in the administration of inappropriate antimicrobial therapy. Primary health care physicians should be alerted to the clinical and laboratory findings of this infection, and pregnant women should routinely be tested serologically in areas where brucellosis is still a problem.
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OBJECTIVE: Human brucellosis is a zoonosis with an extremely wide spectrum of clinical manifestations. Focal splenic involvement is very uncommon, particularly in the pediatric age group, during the illness’ acute phase. CASE REP...
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OBJECTIVE: Human brucellosis is a zoonosis with an extremely wide spectrum of clinical manifestations. Focal splenic involvement is very uncommon, particularly in the pediatric age group, during the illness’ acute phase. CASE REPORT: A 4-year-old boy, already receiving third-generation cephalosporin treatment, was transferred from a local hospital to the University Pediatric Department for fever, anemia, increased inflammation index, and multiple, hyper-echogenic splenic lesions on abdominal ultrasound. Initial diagnostic laboratory investigations for Brucella infection, including the Widal-Wright test, were found to be negative. However, further diagnostic laboratory analysis using the chemiluminescent immunoassay was positive for Brucella IgM antibodies. Treatment with rifampicin at a dose of 150 mg/Kg/twice daily and co-trimethoprim at a dose of 80 mg/Kg/twice daily was started and continued for 7 weeks. IgM antibodies were undetectable after 2 weeks of treatment, and after 6 weeks of treatment, abdominal ultrasound documented a reduction of the diameter of the major splenic infiltrate from 1 to 0.5 cm. At 3 and 5 months of follow-up, re-evaluation of the abdominal lesions displayed complete resolution of the splenic lesions and a complete clinical recovery. CONCLUSIONS: The present case and a literature review are presented in this study since a standard diagnostic laboratory evaluation for brucellosis may miss the diagnosis, and in suspected cases, the laboratory analysis should be extended. Splenic abscesses are known to be rare in brucellosis, but the diagnosis should be considered in children with severe focal lesions, as specific antibiotic treatment may result in complete clinical recovery.
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Authors report incidence of Brucellosis in human in Iraq from 2006 to 2016. We found highest annual incidence rate (IR) in humans was 23 of 100,000 subjects in 2010. This had been reduced to 2.43 of 100,000 by 2016. Thyqar provinc...
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Authors report incidence of Brucellosis in human in Iraq from 2006 to 2016. We found highest annual incidence rate (IR) in humans was 23 of 100,000 subjects in 2010. This had been reduced to 2.43 of 100,000 by 2016. Thyqar province had lowest percentage (0.32%) followed by Basra, Najaf and Missan whereas Salah-Alddin had highest incidence (???%) followed by Sulaymaniah , Nineva and Arbil. The Southern Provinces had less cases (???%) reported lower cases except Muthana and Diwania, while higher casesreported in northern and middle provences.vague By season, most cases were detected during summer 36.25% and lowest in winter 13.71%. Males had a consistently higher IR at all years 64.74% compared with women at 35.26% in Females, By age 15-44 years oldhad the highest percentage 32.80% and those < 1 year old the lowestincidence (hoe%%). We find a large decrease in incidence of Brucellosis in humans in Iraq since 2010 probably due to reduced Brucella spp in animals.
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Human brucellosis is an important animal transmitted disease of man. Although, the cases have been recorded all over the world, the prevalence is higher in developing countries. Lack of sufficient knowledge about the disease among...
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Human brucellosis is an important animal transmitted disease of man. Although, the cases have been recorded all over the world, the prevalence is higher in developing countries. Lack of sufficient knowledge about the disease among the physicians, its under-diagnosis or misdiagnosis and absence of effective prevention and management strategies are attributed to the widespread of the disease. Increase in the occurrence of animal brucellosis has also resulted indirectly in an increase in the prevalence of human infection. Absence of characteristic clinical symptoms, chronic nature of the infection and difficulty in isolation of the causal agent from the patients make the diagnosis of the disease more difficult. The serological tests employed for diagnosing human brucellosis vary in terms of their sensitivity and specificity. Therefore, a combination of serological tests is desirable. Currently no vaccine is available against human brucellosis, which could check the spread of the disease effectively. It issuggested that clinicians investigate the cases of pyrexia of unknown origin (PUO) for brucellosis. It is desirable that specimens from cases of tuberculosis, typhoid, rheumatoid arthritis, urogenital infections, kala-azar, cirrhosis, bacterial endocarditis, leukemia and filariasis should also be screened for brucellosis in man. The cases of meningitis of unestablished etiology as the cases of human brucellosis are often misdiagnosed as cases of typhoid or tuberculosis.
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This retrospective study was performed in two university hospitals between January 2002 and 2006. Ninety-nine brucellosis patients were included in the study. These patients were classified as acute (91), chronic (4) and relapse (...
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This retrospective study was performed in two university hospitals between January 2002 and 2006. Ninety-nine brucellosis patients were included in the study. These patients were classified as acute (91), chronic (4) and relapse (4) according to their clinical presentations and serological tests. Brucella bacteria were isolated in the blood of 17 (17.2%) cases. The most frequent symptom and clinical sign was fever. The osteoarticular complications were found in 17 patients (17.2%). Four of them were complicated with epidural abscess the same time. Two (2.2%) had meningitis, two (2.2%) had epididymoorchitis, three (3.3%) had skin rashes and one (1.1%) had hepatitis. Three of the acute brucellosis patients were pregnant. Rifampin and doxycycline combination therapy had been administered to most of the patients with acute and relapse brucellosis. However, complicated and chronic brucellosis cases were given different treatment combinations. This study reviews brucellosis therapy choices.
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Brucellosis is primarily a zoonotic disease that continues to be an important public health problem. It is a rare, multisystem infection of childhood and it may present with a wide spectrum of clinical presentations and complicati...
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Brucellosis is primarily a zoonotic disease that continues to be an important public health problem. It is a rare, multisystem infection of childhood and it may present with a wide spectrum of clinical presentations and complications. However, lung involvement is extremely rare in the course of childhood brucellosis. This case report describes a 6-year-old child who was referred to our hospital as meningococcemia but diagnosed as lobar pneumonia in follow-up. Brucella agglutination test and bone marrow culture were diagnostic of brucellosis. The patient responded to the combination therapy of rifampicin and trimethoprim-sulfamethoxazole.
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Brucellosis is the most common zoonosis in the world and it is caused by ingestion of foods contaminated by Brucella spp. that is able to avoid the immune system and can involve every organ system. The bacteria may affect the Cent...
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Brucellosis is the most common zoonosis in the world and it is caused by ingestion of foods contaminated by Brucella spp. that is able to avoid the immune system and can involve every organ system. The bacteria may affect the Central Nervous System (CNS) directly or using phagocytic cells with the way of the "Trojan Horse Model".
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Brucellosis is a serious public health issue in India. Estimation of economic losses occurring due to brucellosis is required to help formulate prevention and control strategies, but has not been done in India. We estimated econom...
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Brucellosis is a serious public health issue in India. Estimation of economic losses occurring due to brucellosis is required to help formulate prevention and control strategies, but has not been done in India. We estimated economic losses due to brucellosis by sourcing prevalence data from epidemiological surveys conducted in India. Data for livestock populations were obtained from official records. Probability distributions were used for many of the input parameters to account for uncertainty and variability. The analysis revealed that brucellosis in livestock is responsible for a median loss of US $ 3.4 billion (5th-95th percentile 2.8-4.2 billion). The disease in cattle and buffalo accounted for 95.6% of the total losses occurring due to brucellosis in livestock populations. The disease is responsible for a loss of US $ 6.8 per cattle, US$18.2 per buffalo, US $ 0.7 per sheep, US $ 0.5 per goat and US $ 0.6 per pig. These losses are additional to the economic and social consequences of the disease in humans. The results suggest that the disease causes significant economic losses in the country and should be controlled on a priority basis. (C) 2015 Elsevier B.V. All rights reserved.
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A cross-sectional study was conducted from December 2019 to May 2020 to determine the seroprevalence and identify potential risk factors of brucellosis in dairy cows and owners. Purposive sampling was performed in the respective f...
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A cross-sectional study was conducted from December 2019 to May 2020 to determine the seroprevalence and identify potential risk factors of brucellosis in dairy cows and owners. Purposive sampling was performed in the respective farms and kebeles to screen recent cases of abortion. The overall seroprevalence of bovine and human brucellosis was 0.61% (95%CI:0.016–2.09) and 1.21% (95%CI:0.032–4.27) respectively using combined RBPT and CFT tests. Late stage of abortion (OR?= 14 .74, p =?0.0002), retained fetal membrane (OR?=?32.74, p =?0.006), market-based stock replacement (OR?= 16 .55, p =?0.002), and presence of parturition pen (OR?= 11 .511, p =?0.027) was found to be significantly associated with seropositivity for Brucella infection in dairy cattle. Human housing (OR?= 1 .8, p =?0.002), contact with aborted fetus (OR?=?21.19, p =?0.017), and drinking raw milk from aborted (OR?=?5.72, 0.019) and retained fetal membrane (OR?=?4.22, p =?0.029) cows all had a significant influence on human brucellosis seropositivity. A structured interview question was administered to 284 respondents. Accordingly, most respondents had no knowledge of bovine brucellosis and their zoonotic effects (93.3%) in contrast most of them drink raw milk. Implementation of a test and slaughter strategy with compensation is recommended with this low prevalence. In the case of human brucellosis, implementing one health approach framework should be practiced.
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Бруцеллез - широко распространенная инфекционная болезнь, имеет склонность к хроническому течению с полиорганным поражением...
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Бруцеллез - широко распространенная инфекционная болезнь, имеет склонность к хроническому течению с полиорганным поражением. Цель исследования - анализ клинических проявлений хронического бруцеллеза и резидуального бруцеллеза у больных из профессиональных групп риска. Материал и методы. На базе центра профессиональной патологии г. Омска были обследованы 120 человек (83 женщины, 37 мужчин) с диагнозом ?бруцеллез?. Проведены ретроспективный эпидемиологический и эпизоотологический анализы заболеваемости бруцеллезом на территории Омской области за 15-летний период и простое кросс-секционное клиническое исследование. Результаты и обсуждение. Клиническая картина хронического и резидуального бруцеллеза во всех случаях характеризовалась поражением локомоторного аппарата и в 90,8% случаев сочеталась с вовлечением разных отделов нервной системы, что необходимо учитывать при диагностике болезни в группах профессионального риска заражения возбудителем бруцеллеза. Заключение. Необходимо повысить качество периодических осмотров уязвимого контингента. Организация медицинской помощи пациентам должна включать участие невролога, ревматолога и психиатра с проведением реабилитации в профильных отделениях и санаториях.
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