摘要 : Chemotherapy resistance is the main reason for the failure of cancer treatment. The mechanism of drug resistance is complex and diverse. In recent years, the role of glucose metabolism and mitochondrial function in cancer resistan... 展开 Chemotherapy resistance is the main reason for the failure of cancer treatment. The mechanism of drug resistance is complex and diverse. In recent years, the role of glucose metabolism and mitochondrial function in cancer resistance has gathered considerable interest. The increase in metabolic plasticity of cancer cells' mitochondria and adaptive changes to the mitochondrial function are some of the mechanisms through which cancer cells resist chemotherapy. As a key molecule regulating the mitochondrial function and glucose metabolism, PGC-1 alpha plays an indispensable role in cancer progression. However, the role of PGC-1 alpha in chemotherapy resistance remains controversial. Here, we discuss the role of PGC-1 alpha in glucose metabolism and mitochondrial function and present a comprehensive overview of PGC-1 alpha in chemotherapy resistance. 收起