摘要
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Morphogenetic processes during brain development and postdevelopmental remodeling of neural archi-tecture depend on the exquisite interplay between the microtubule-and actin-based cytoskeletal systems. Accumulation of evidence ind...
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Morphogenetic processes during brain development and postdevelopmental remodeling of neural archi-tecture depend on the exquisite interplay between the microtubule-and actin-based cytoskeletal systems. Accumulation of evidence indicates cooperative roles of another cytoskeletal system composed of the septin family. Here we overview experimental findings on mammalian septins and their hypo-thetical roles in the proliferation of neural progenitor cells, neurite development, synapse formation and regulations. The diverse, mostly unexpected phenotypes obtained from gain-and loss-of-function mutants point to unknown molecular network to be elucidated, which may underlie pathogenetic pro-cesses of infectious diseases and neuropsychiatric disorders in humans. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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