摘要 : A copper-(II)-P,N,N-ligand catalyzed propargylic [3 +2] cycloadditionapproach for the synthesis of optically enriched dihydrofuro-[3,2-c]-coumarins has been accomplished for the first time. Thecycloaddition utilizes propargylic es... 展开 A copper-(II)-P,N,N-ligand catalyzed propargylic [3 +2] cycloadditionapproach for the synthesis of optically enriched dihydrofuro-[3,2-c]-coumarins has been accomplished for the first time. Thecycloaddition utilizes propargylic esters as C2-bis-electrophilesand 4-hydroxycoumarin derivatives as C,O-bis-nucleophiles. In addition,this novel strategy was also explored with 4-hydroxy-2-quinolinonesand 4-hydroxythiocoumarins. Moreover, various dihydrofuro-[3,2-c]-coumarins and their quinolinone and thiocoumarin analogueswere synthesized in moderate to good yields with high enantioselectivities. 收起