摘要 : While various porous scaffolds have been developed, the focused study about which structure leads tobetter mechanics is rare. In this study, we designed porous scaffolds with tetragonal, hexagonal andwheel-like structures under a ... 展开 While various porous scaffolds have been developed, the focused study about which structure leads tobetter mechanics is rare. In this study, we designed porous scaffolds with tetragonal, hexagonal andwheel-like structures under a given porosity, and fabricated corresponding poly(lactic acid) (PLA)scaffolds with three-dimensional printing. High-resolution micro-computed tomography was carriedout to calculate their experimental porosity and confirm their high interconnectivity. The theoreticaland experimental compressive properties in the longitudinal direction were characterized by finiteelement analysis method and electromechanical universal testing system, respectively. Thereinto, thescaffold with the tetragonal structure exhibited higher mechanical strength both theoretically andexperimentally. Creep and stress relaxation behaviors of the scaffolds revealed that the tetragonalscaffold had less significant viscoelasticity. Immersion dynamic mechanical analysis was performed totest their cycle-loading fatigue behaviors in the simulated body fluid at 37 °C; the tetragonal scaffoldexhibited the latest fatigue beginning point at 4400 cycles, which indicated a better anti-fatigueperformance; the hexagonal and wheel-like ones exhibited the middle and earliest fatigue beginningpoints at 3200 and 2500 cycles, respectively. What is more, cytocompatibility and histocompatibilityof the scaffolds with all of the structures were confirmed by cell counting kit-8 assay in vitro and threemonthsubcutaneous implantation in ratsin vivo. Hence, the key property difference of the threeexamined structures comes from their mechanics; the tetragonal structure exhibited better mechanicsin the longitudinal direction examined in this study, which could be taken into consideration in designof a porous scaffold for tissue engineering and regeneration. 收起