摘要 : There has been significant interest to finding new and effective bactericidal materials due to increasing antibiotic resistance. Herein, this work reports on the design of a chitosan nanocomposite (NC) with two nanoparticle (NP) c... 展开 There has been significant interest to finding new and effective bactericidal materials due to increasing antibiotic resistance. Herein, this work reports on the design of a chitosan nanocomposite (NC) with two nanoparticle (NP) components, silver (Ag) and curcumin nanoparticles (Cur-NPs) with enhanced antibacterial activity. Chitosan-silver curcumin NC (Chi-Ag Cur NC) was prepared by adding water-soluble Cur-NPs to Chi-Ag NC solution. In order to produce Chi-Ag NC in a green manner, silver nanoparticles (Ag-NPs) were synthesized through photochemical reduction by using chitosan as the stabilizing agent and acetic acid as the reducing agent. The characteristics of Chi-Ag Cur NC were investigated through UV-Vis spectroscopy, FTIR, XRD, EDX, SEM, and DLS analysis. Chi-Ag Cur NC's antibacterial activity was further tested against certain clinically isolated strains of burn wound infection with significant antibiotic resistance as well as some standard bacterial strains. An increase in antimicrobial/antibiofilm activity of Chi-Ag Cur NC was observed with lower MIC and MBIC. In addition, no cytotoxicity of freshly produced NC was seen in NHDF cells. These results clearly revealed the synergy of Ag-NPs and Cur-NPs in novel antibacterial NC film which can be applicable as a promising antibacterial coating to prevent infection and promote burn wound healing. 收起