摘要 : Purpose: To assess the value of radiomics, apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and stretched-exponential (SE) MR imaging in prediction of therapeutic response in patients with spinal metastase... 展开 Purpose: To assess the value of radiomics, apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and stretched-exponential (SE) MR imaging in prediction of therapeutic response in patients with spinal metastases before chemotherapy. Methods: Thirty-six patients with 190 osteolytic metastatic lesions from breast cancer were prospectively enrolled and underwent MR imaging before and after 6 months' treatment on a 1.5 T MRI. According to MDA criteria, 68 lesions were categorized as progressive disease (PD) and 122 lesions were categorized as stable or improvement (non-PD). The regions of interest (ROIs) were manually drawn on DWI, T1WI, T2WI and FS-T2WI by two radiologists with ITK-SNAP. The ADCall (multiple b-values method), IVIM parameters (D, D* and f) and SE parameters (DDC and alpha) were generated. The radiomics features were extracted from the ROIs. Results: The mean values of ADC, DDC, and D before treatment were significantly higher in non-PD group than those in PD group (P = 0.001). The radiomics based on ADCall had the highest AUC value (0.852), followed by that of the T2WI (0.829) and FS-T2WI (0.798). The radiomics model using ADCall and FS-T2WI showed excellent efficiency in predicting treatment response with AUCs of 0.905 and 0.873 in training and validation cohorts. The radiomics model had better performance than that of ADCall, D, and DDC for predicting treatment response of bone metastases. Conclusion: Radiomics model based on ADCall and FS-T2WI could predict the treatment response and contribute to assisting clinicians in accurately choosing appropriate management. 收起