摘要 : Catalytic asymmetric conjugate arylation of racemic 6-substituted cyclohexenones with aryl-boronic acids was catalyzed by 3 mol % of chiral amidophosphane-[RhCl(C2H4)](2) in a 10:1 mixture of 1,4-dioxane and water at 70 degrees C ... 展开 Catalytic asymmetric conjugate arylation of racemic 6-substituted cyclohexenones with aryl-boronic acids was catalyzed by 3 mol % of chiral amidophosphane-[RhCl(C2H4)](2) in a 10:1 mixture of 1,4-dioxane and water at 70 degrees C to afford a nearly 1:1 mixture of trans- and cis-5-aryl-2-substituted cyclohexanones in high enantioselectivity, which was subsequently epimerized with sodium ethoxide in ethanol to give thermodynamically stable traps-5-aryl-2-substituted cyclohexanones with 99-97% ee in high two-step yields. 收起