摘要 : The anti-inflammatory activity of Cleome arabica leaf extract was studied in vivo and in vitro. Firstly, the extract was examined for its anti-inflammatory activity using car-rageenan-induced rat paw edema as a model of acute infl... 展开 The anti-inflammatory activity of Cleome arabica leaf extract was studied in vivo and in vitro. Firstly, the extract was examined for its anti-inflammatory activity using car-rageenan-induced rat paw edema as a model of acute inflammation. A subplantar injection of 0.lml of carrageenan 1% induced a progressive swelling of the rat paw in all time points, that reached a maximal volume in .placebo group within 5h. Results showed that pre-treatment of rats by Cleome arabica leaf extract, 1h prior the injection of the phlogogenic agent, prevented the increase of the edema in dose-dependent manner with an ED_(50) of 231 mg/kg, body weight. The extract doses 100, 200 and 300 mg/kg, reduced edema to 65.54 (+-) 5.2%, 57.86 (+-) 8%, and 41.54 (+-) 3.6%, respectively, 5 h after the carrageenan injection. Secondly, we have examined the effect of Cleome arabica leaf extract on human neutrophil migration induced by fMLP (10~7M), using 48-well chemotaxis chamber. Results showed that the extract inhibited neutrophil chemotaxis significantly (p < 0.01) and in a dose-dependent manner. Neutrophil migration was reduced to 16.71 (+-) 4.6% in presence of 50 fig/ml of Cleome arabica leaf extract. It appears that the anti-inflammatory activity of Cleome arabica leaf extract, observed in vivo as well as in vitro, could be due to its high flavonoid content (19%). These results may contribute to explain the use of this plant in folk medicine. 收起