摘要 : Phosgene and triphosgene are both powerful reagents to access to key speciality chemicals. The hazards associated with the use of phosgene are well known and documented. However, with effective safety management these reagents pro... 展开 Phosgene and triphosgene are both powerful reagents to access to key speciality chemicals. The hazards associated with the use of phosgene are well known and documented. However, with effective safety management these reagents proved to be highly efficient tools. Triphosgene, regarded by many as a "safer" form of phosgene doesn't take advantage from the same risk assessment. When the toxicity, stability and reactivity data of triphosgene are evaluated and completed by a calorimetric comparison with phosgene, the data generated confirms the necessity for an exhaustive hazard analysis before implementing the use of triphosgene in any and all chemical processes. A balanced score card approach to risk management versus phosgene highlights and emphasises that for a safe triphosgene management, the best strategy is to confer the synthesis to a phosgene expert. 收起