摘要 : Sonodynamic therapy demonstrates tremendous potential in biomedicinedue to its non-invasiveness, deep tissue penetration, and spatiotemporalcontrollability. However, the lack of favorable nanosonosensitizers withprominent reactive... 展开 Sonodynamic therapy demonstrates tremendous potential in biomedicinedue to its non-invasiveness, deep tissue penetration, and spatiotemporalcontrollability. However, the lack of favorable nanosonosensitizers withprominent reactive oxygen species generation capability and green chemicalconstituents remains a significant challenge for its broad biomedical applications.Herein, a homologous bismuth-based nanosonosensitizer (Bi-HJ) isdesigned and fabricated by direct defect engineering for combinational tumortherapy. Specifically, self-derived Schottky heterojunction and oxygen vacanciesare concurrently constructed in Bi-HJ, which prominently promotes theseparation of ultrasound-triggered electron–hole pairs and improves thecharge utilization efficiency. With the porous structure, Bi-HJ is loaded witha metabolic regulation drug atovaquone to block the mitochondrial respirationfor oxygen-economized sonodynamic tumor suppression. The strongnear-infrared absorption of Bi-HJ imparted by oxygen vacancies allowsthe implementation of photothermal therapy. Accordingly, Bi-HJ rationallycombines two therapeutic modalities and metabolic regulation function, aswell as computed tomography imaging ability, thus achieving effective tumortheranostics in vitro and in vivo. Therefore, this study provides new insightinto the fabrication of homologous nanosonosensitizers without the introductionof other constituents for synergistically enhanced tumor therapy. 收起