摘要 : Fullerene (C_(60)) exhibits versatile properties that shows great potential for improving water treatment technologies. However, the probable transformation of C_(60) during water treatment, which consequently changes the physicoc... 展开 Fullerene (C_(60)) exhibits versatile properties that shows great potential for improving water treatment technologies. However, the probable transformation of C_(60) during water treatment, which consequently changes the physicochemical properties and toxicity of the parent compound, may introduce doubt concerning its application. Our results demonstrated that the C_(60) aggregate (nC_(60)) was transformed to a more oxidized form under common water disinfection processes (i.e., ultraviolet irradiation and photochlorination). The light-irradiated product (UV_nC_(60)) exhibited lower cytotoxicity toward macrophage J774A.1 cells relative to Nc_(60). Whereas the photochlorinated product (UV/Cl_Nc_(60)) increased the toxic effect Particularly, the internalization of nanoparti-cles and the mimetic superoxide dismutase (SOD) activity resulted in the selective accumulation of intracellular hydrogen peroxide. Thus, sequential exposure to a nonlethal dose of nanoparticles followed by 5 Μm copper ions (which is a much lower level than the EPA-regulated level of 20 Μm in drinking water) led to the significant production of hydroxyl radicals inside cells. The uptake and SOD-like activity were highly structure-related, with the most noteworthy activity obtained for UV/Cl_Nc_(60). These results emphasize that environmental transformation-induced property changes should be given adequate consideration in the risk assessment of C_(60). 收起