摘要 : ABSTR A C T Resistance to Ceftazidime-Avibactam in Enterobacter cloacae is poorly understood. Whole genome sequenc-ing identified 6 variants in isolates collected from a patient before and after acquiring Ceftazidime-Avibac-tam re... 展开 ABSTR A C T Resistance to Ceftazidime-Avibactam in Enterobacter cloacae is poorly understood. Whole genome sequenc-ing identified 6 variants in isolates collected from a patient before and after acquiring Ceftazidime-Avibac-tam resistance. This included a Phe396Leu mutation in acrB, a component of the AcrAB-TolC efflux pump, possibly mediating enhanced efflux of Ceftazidime and/ or Avibactam. (c) 2021 Elsevier Inc. All rights reserved. 收起