摘要 :
Internal repeats are widely found in proteins and considered to be important in protein evolution and function. Three major types of internal repeat including domain, solenoid, and fibrous repeats are. These repeats may involve in...
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Internal repeats are widely found in proteins and considered to be important in protein evolution and function. Three major types of internal repeat including domain, solenoid, and fibrous repeats are. These repeats may involve in protein-protein interaction as well as binding to various ligands such as DNA and RNA. For example, the tetratrico peptide repeats (TPR) that are involved in cell-cycle regulation, transcriptional regulation, protein transport, and assisting protein folding, and the TATA-binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence. To identify and classify various types of protein repeats with different lengths from a query protein sequence or structure, we have designed a comprehensive system which focuses on analyzing autocorrelation relationships of sequence contents and topology of secondary structures within a protein. A complete database containing verified fundamental repeat sequence peptides and structural units for homologous matching analysis is also constructed. The data flow diagram of the proposed identification system contains two major parts: Repeat Database and Internal Repeat Analyzer. The Repeat Database is constructed by evaluating proteins from SCOP and Pfam through an autocorrelation mechanism. The Internal Repeat Analyzer is designed as a three-level hierarchical analysis for detecting domain, solenoid, and fibrous repeat respectively. In addition, an iteratively refined multiple structure alignment tool has been developed for comparing and verifying those extracted internal repeat substructures. In this study, the collected database contains 162 domain families with repeat characteristics, 28 fundamental repeat structure units and 129 repeat subsequences retrieved from 1,961 superfamilies, and we have demonstrated the proposed system can efficiently identify repeat topologies of proteins.
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摘要 :
Internal repeats are widely found in proteins and considered to be important in protein evolution and function. Three major types of internal repeat including domain, solenoid, and fibrous repeats are. These repeats may involve in...
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Internal repeats are widely found in proteins and considered to be important in protein evolution and function. Three major types of internal repeat including domain, solenoid, and fibrous repeats are. These repeats may involve in protein-protein interaction as well as binding to various ligands such as DNA and RNA. For example, the tetratrico peptide repeats (TPR) that are involved in cell-cycle regulation, transcriptional regulation, protein transport, and assisting protein folding, and the TATA-binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence. To identify and classify various types of protein repeats with different lengths from a query protein sequence or structure, we have designed a comprehensive system which focuses on analyzing autocorrelation relationships of sequence contents and topology of secondary structures within a protein. A complete database containing verified fundamental repeat sequence peptides and structural units for homologous matching analysis is also constructed. The data flow diagram of the proposed identification system contains two major parts: Repeat Database and Internal Repeat Analyzer. The Repeat Database is constructed by evaluating proteins from SCOP and Pfam through an autocorrelation mechanism. The Internal Repeat Analyzer is designed as a three-level hierarchical analysis for detecting domain, solenoid, and fibrous repeat respectively. In addition, an iteratively refined multiple structure alignment tool has been developed for comparing and verifying those extracted internal repeat substructures. In this study, the collected database contains 162 domain families with repeat characteristics, 28 fundamental repeat structure units and 129 repeat subsequences retrieved from 1,961 superfamilies, and we have demonstrated the proposed system can efficiently identify repeat topologies of proteins.
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Hyperspectral remote sensing imaging systems are measuring instruments whereby the spectrum of each pixel in the target image may be used to quantify or identify its properties. Hyperspectral image cubes acquired in consecutive fl...
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Hyperspectral remote sensing imaging systems are measuring instruments whereby the spectrum of each pixel in the target image may be used to quantify or identify its properties. Hyperspectral image cubes acquired in consecutive flights over the same target, should ideally be identical but in practice there are significant differences between them. These differences are due to variations in: target characteristics, solar illumination, atmospheric conditions and errors of the imaging system proper. When the non-repeatability variance is similar in magnitude to the variance of the spectral or spatial information of interest, it would be impossible to use it for classification or quantification prediction modeling. Modus operandi is presented for objective assessment of spatial and spectral repeatability by multiple image cube acquisitions, wherein the imaging system views a Barium Sulfate (BaSO4) painted panel illuminated by a Halogen lamp and by consecutive flights over a reference target.
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摘要 :
Hyperspectral remote sensing imaging systems are measuring instruments whereby the spectrum of each pixel in the target image may be used to quantify or identify its properties. Hyperspectral image cubes acquired in consecutive fl...
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Hyperspectral remote sensing imaging systems are measuring instruments whereby the spectrum of each pixel in the target image may be used to quantify or identify its properties. Hyperspectral image cubes acquired in consecutive flights over the same target, should ideally be identical but in practice there are significant differences between them. These differences are due to variations in: target characteristics, solar illumination, atmospheric conditions and errors of the imaging system proper. When the non-repeatability variance is similar in magnitude to the variance of the spectral or spatial information of interest, it would be impossible to use it for classification or quantification prediction modeling. Modus operandi is presented for objective assessment of spatial and spectral repeatability by multiple image cube acquisitions, wherein the imaging system views a Barium Sulfate (BaSO4) painted panel illuminated by a Halogen lamp and by consecutive flights over a reference target.
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Repeat finding has been given little attention in most published complete prokaryotic genome annotations, yet repeated sequences are ubiquitous in prokaryotic genomes. Without identifying the repetitive deoxyribonucleic acid (DNA)...
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Repeat finding has been given little attention in most published complete prokaryotic genome annotations, yet repeated sequences are ubiquitous in prokaryotic genomes. Without identifying the repetitive deoxyribonucleic acid (DNA) in genomes, it not only makes systematical characterization of the prokaryotic repeats impossible, it leaves the genome annotations incomplete, resulting in a barrier to genome analysis. We have developed a software package that can identify repeats in the whole prokaryotic genome from the DNA sequence.
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This paper examines precision of the contour method using five residual stress measurement repeatability studies. The test specimens evaluated include: an aluminum T-section, a stainless steel plate with a dissimilar metal slot-fi...
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This paper examines precision of the contour method using five residual stress measurement repeatability studies. The test specimens evaluated include: an aluminum T-section, a stainless steel plate with a dissimilar metal slot-filled weld, a stainless steel forging, a titanium plate with an electron beam slot-filled weld, and a nickel disk forging. These specimens were selected to encompass a range of typical materials and residual stress distributions. Each repeatability study included contour method measurements on five to ten similar specimens. Following completion of the residual stress measurements an analysis was performed to determine the repeatability standard deviation of each population. In general, the results of the various repeatability studies are similar. The repeatability standard deviation tends to be relatively small throughout the part interior and there are localized regions of higher repeatability along the part perimeter. The repeatability standard deviations over most of the cross-section range from 5 MPa, for the aluminum T-section, to 35 MPa, for the stainless steel forging. These results provide expected precision data for the contour method over a broad range of specimen geometries, materials, and stress profiles.
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Many Assembled products have ever shorter lifecycles while the demand for ultra-precision continuously increases. Modular assembly systems are design to address the need for volume and product variations and need to increasingly a...
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Many Assembled products have ever shorter lifecycles while the demand for ultra-precision continuously increases. Modular assembly systems are design to address the need for volume and product variations and need to increasingly address demand for higher accuracy and repeatability. This paper proposes a new methodology for the repeatability synthesis of modular assembly workstations based on the basic characteristics of their modules. The methodology simultaneously takes the physical configuration of the modules and the process setup of their skills into consideration.
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A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the per...
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A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the periodic sequences causes the segmental duplication that is a type of chromosomal structural arrangement In this study, we analyze the relationships between die large-scale segmental duplication of chromosome and die periodic sequences. For this purpose, the periodic sequences are detected by two repeat detection tools, TRF and STEPSTONE, to detect repeats of genomic sequence, and the distribution of detected periodic sequences is corresponded with the locations on the chromosome where the segmental duplications are observed.
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摘要 :
A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the per...
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A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the periodic sequences causes the segmental duplication that is a type of chromosomal structural arrangement. In this study, we analyze the relationships between the large-scale segmental duplication of chromosome and the periodic sequences. For this purpose, the periodic sequences are detected by two repeat detection tools, TRF and STEPSTONE, to detect repeats of genomic sequence, and the distribution of detected periodic sequences is corresponded with the locations on the chromosome where the segmental duplications are observed.
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摘要 :
A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the per...
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A various types of repeat sequences are abundant in genomic sequence, and are associated with the biological phenomena at distinct levels. In particular, comparative analyses of whole-genome-sized sequence data reveal that the periodic sequences causes the segmental duplication that is a type of chromosomal structural arrangement In this study, we analyze the relationships between die large-scale segmental duplication of chromosome and die periodic sequences. For this purpose, the periodic sequences are detected by two repeat detection tools, TRF and STEPSTONE, to detect repeats of genomic sequence, and the distribution of detected periodic sequences is corresponded with the locations on the chromosome where the segmental duplications are observed.
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