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Context. Patients with breast cancer who undergo chemotherapy (CTX) experience between 10 and 32 concurrent symptoms. An evaluation of how these symptoms cluster together and how these symptom clusters change over time may provide...
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Context. Patients with breast cancer who undergo chemotherapy (CTX) experience between 10 and 32 concurrent symptoms. An evaluation of how these symptoms cluster together and how these symptom clusters change over time may provide insights into how to treat these multiple co-occurring symptoms.
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This paper describes the probable cause of vasomotor symptoms during climacterics and before menstruation/ovulation. We propose that sex hormones imbalance changes the elasticity, resonance frequencies, and resonance peaks of vasc...
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This paper describes the probable cause of vasomotor symptoms during climacterics and before menstruation/ovulation. We propose that sex hormones imbalance changes the elasticity, resonance frequencies, and resonance peaks of vascular beds primarily in the uterus/intestines. It is also explained that vasomotor symptoms occur in the locations which resonate blood flow from the uterus/intestines for the above reason.
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Almost all depression measures have been developed without discussing how to best conceptualize and assess the severity of depression. The most valid rating format of depression severity scales is unsettled and has been little stu...
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Almost all depression measures have been developed without discussing how to best conceptualize and assess the severity of depression. The most valid rating format of depression severity scales is unsettled and has been little studied. In the present study from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we compared the validity of alternative approaches towards rating the severity of depressive symptoms. Data was collected using TurkPrime. One hundred eighty-five participants currently in treatment for a mental health problem completed a self-report measure of depression and rated the symptoms on two 4-point ordinal scales assessing symptom frequency and symptom intensity. The respondents also rated their global level of depression severity and completed a measure of psychosocial functioning and quality of life. The symptom ratings based on intensity and frequency were highly correlated with each other, and equally highly correlated with subjects' global rating of overall severity of depression, as well as ratings of psychosocial functioning and quality of life. A composite index of severity based on the sum of frequency and severity ratings was no more highly correlated with the external validators. The results of the present study suggest that ratings of depressive symptoms based on either symptom intensity or symptom frequency are equally valid.
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Background Few studies have examined gender-specific pathways in the intergenera-tional transmission of internalising and externalising behaviours across threegenerations.Aim The current study considered both parental figures' int...
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Background Few studies have examined gender-specific pathways in the intergenera-tional transmission of internalising and externalising behaviours across threegenerations.Aim The current study considered both parental figures' internalising and externalis-ing symptoms simultaneously and tested path models of the transmission of internalis-ing and externalising symptoms from Generation 1 (G1) to Generation 2 (G2) andfrom G2 to Generation 3 (G3) by focusing on gender-specific pathways.Method The study used data from the Oregon Youth Study of 206 young men andtwo associated studies of their intimate partners (Couples Study) and children (Three-Generational Study) over 20 years.Results Findings indicated that, in general, mothers' internalising behaviour showedrobust influence on offspring's internalising symptoms across three generations, regard-less of gender of the child. G2 men's externalising behaviour was further predicted byG1 mothers' internalising as well as externalising behaviour, albeit the latter was onlymarginally significant. G3 girls' internalising and externalising behaviour was pre-dicted by their fathers' corresponding behaviour. Overall, fathers' influence on theirsons was limited.Conclusion The findings shed important light on potential gender-specific mecha-nisms of intergenerational transmission of internalising and externalising behaviour.
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The presence of hoarding symptoms in patients with obsessive-compulsive disorder (OCD) is a commonly reported phenomenon. How these symptoms are to be understood is less clear. The extent to which hoarding fits with other symptoms...
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The presence of hoarding symptoms in patients with obsessive-compulsive disorder (OCD) is a commonly reported phenomenon. How these symptoms are to be understood is less clear. The extent to which hoarding fits with other symptoms of OCD by considering its diagnostic utility and underlying cognitive processes is evaluated. In the first stud); hoarding symptoms did not differentiate OCD patients from individuals with other anxiety disorders or unscreened students, indicating that hoarding does not inform diagnostic decision making. In the second stud); using an independent nonclinical sample, cognitive variables related to OCD were distinct from hoarding-specific cognitions, and not predictive of hoarding symptoms. These results add to a growing body of evidence suggesting that hoarding is not a symptom or manifestation of OCD. The need for careful assessment of the function of hoarding symptoms is discussed.
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Heart failure (HF) symptoms are known to influence depressive symptoms, yet a symptom profile has not been identified. HF symptoms relative to symptom experience (frequency, severity, interference with physical activity and enjoym...
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Heart failure (HF) symptoms are known to influence depressive symptoms, yet a symptom profile has not been identified. HF symptoms relative to symptom experience (frequency, severity, interference with physical activity and enjoyment of life) associated with depressive symptoms were examined. Data from three HF studies ( N = 308) which used the Heart Failure Symptom Survey were included in this cross-sectional secondary analysis. Supervised classification for and identification of symptoms most associated with depressive symptoms were accomplished using random forest algorithms via conditional inference trees. The HF symptom profile associated with depressive symptoms across all four symptom experience domains included fatigue, dizziness, and forgetfulness/difficulty concentrating. Abdominal bloating, worsening cough, and difficulty sleeping were also important, but did not consistently rank in the top 5 for symptom importance relative to all symptom experience domains. Symptom profiling may enhance early identification of patients at risk for depressive symptoms and inform symptom management interventions.
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PROBLEM IDENTIFICATION: Symptom experience in patients with cancer consists of several dimensions, often measured descriptively within various populations but seldom used as intervention outcomes. This review aims at describing sy...
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PROBLEM IDENTIFICATION: Symptom experience in patients with cancer consists of several dimensions, often measured descriptively within various populations but seldom used as intervention outcomes. This review aims at describing symptom dimensions as outcomes of interventions designed to alleviate symptoms in patients with cancer and to describe these interventions' effects on at least two symptom dimensions.
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Context. The relatively low number of older patients in cancer trials limits knowledge of how older adults experience symptoms associated with cancer and its treatment.
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Few instruments have been developed and validated for the evaluation of multi-dimensional GI symptoms. The Gastrointestinal Symptoms Severity Index (GISSI), a multi-dimensional, self-report instrument, was designed as a brief meas...
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Few instruments have been developed and validated for the evaluation of multi-dimensional GI symptoms. The Gastrointestinal Symptoms Severity Index (GISSI), a multi-dimensional, self-report instrument, was designed as a brief measure of the frequency, severity, and bothersomeness of individual GI and pelvic floor/urogynecologic symptoms.
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Comparing subgroups with different patterns of change in symptom intensity would assist in sorting out individuals at risk for more severe symptoms and worse functional outcomes. OBJECTIVES:: The objectives of this study were to i...
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Comparing subgroups with different patterns of change in symptom intensity would assist in sorting out individuals at risk for more severe symptoms and worse functional outcomes. OBJECTIVES:: The objectives of this study were to identify and compare subgroups of breast cancer patients with different patterns of change in a psychoneurological symptom cluster intensity across the treatment trajectory. METHODS:: This secondary analysis used the data from 160 breast cancer patients undergoing chemotherapy or radiation treatment. Psychoneurological symptom cluster intensity was a composite score of 5 symptoms (depressed mood, cognitive disturbance, fatigue, insomnia, and pain) in a psychoneurological cluster at each of 3 time points (ie, at baseline and at 2 follow-ups after chemotherapy or radiation treatment). RESULTS:: Five distinct subgroups representing different patterns of psychoneurological symptom cluster intensity during breast cancer treatment were identified: the gradually increasing pattern subgroup (group 1), the constantly low pattern subgroup (group 2), the start low with dramatic increase and decrease pattern subgroup (group 3), the constantly high pattern subgroup (group 4), and the start high with dramatic decrease and leveling pattern subgroup (group 5). Patients without previous cancer treatment experience, with higher level of education, treated with chemotherapy, and/or with more limitations at the baseline were more likely to follow the pattern group 4. Patients in group 4 had the most serious functional limitations measured at the second follow-up time point. CONCLUSION:: The results suggest the need to evaluate interventions for specific subgroups and to examine the causal mechanisms underlying a psychoneurological symptom cluster. IMPLICATION:: Clinicians should consider these diverse symptom experiences for assessment/management.
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