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The present research studies the effects of sarmesin [Sar(1)Tyr(OMe)(4)] Angiotensin II (ANG II), an analogue of ANG II, on the seizure susceptibility, memory activity and nociception. It was found that this octapeptide, administe...
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The present research studies the effects of sarmesin [Sar(1)Tyr(OMe)(4)] Angiotensin II (ANG II), an analogue of ANG II, on the seizure susceptibility, memory activity and nociception. It was found that this octapeptide, administered i.c.v., dose-dependently decreased the seizure intensity (pentylenetetrazol (PTZ) generalized seizure model and PTZ kindling) and augmented PTZ seizure threshold in mice. Sarmesin impaired the memory upon re-testing of rats 24 h later in the passive avoidance test. It decreased the pain threshold in a paw pressure nociceptive assay in rats. ANG II exerted pronociceptive effect as well. Taken together, these results reveal sarmesin as a behaviorally active peptide in the studied experimental animal models.
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The binary and ternary (bpy) palladium(II) complexes of the N-sulfonyl derivatives of asparagine and glutamine were studied by polarography and electronic spectra as a function of pH and metal-to-ligand molar ratio. Binary [Pd(L-N...
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The binary and ternary (bpy) palladium(II) complexes of the N-sulfonyl derivatives of asparagine and glutamine were studied by polarography and electronic spectra as a function of pH and metal-to-ligand molar ratio. Binary [Pd(L-NO)] and [Pd(L-NO)(2)](2-) complexes are formed below pH 4, in which the N-sulfonyl-aminoacids act as bidentate N,O-chelate ligands through the deprotonated sulfonamide nitrogen and the carboxylate oxygen. No other binary species are detected at higher pH values. Both ligands form the ternary complex [Pd(L-NO)(bpy)] below pH 8.5. At higher pH values, the electrochemical and spectral data indicate that the ligands undergo an acid-base equilibrium with an apparent pK(a) value of about 10, which most probably corresponds to the deprotonation and metal coordination of the amide nitrogen of the side-chain. The overall stability constants for the binary and ternary complexes were determined polarographically and discussed in comparison with those for the homologous species formed by N-sulfonyl-aminoacids with a non-coordinating side-chain. (C) 1998 Elsevier Science S.A. All rights reserved. [References: 13]
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This work studies the effect of NTMP (nitrilotris(methylenephosphonic acid))on the adsorption of Cu(II), Zn(II), and Cd(II)onto boehmite in the pH range 5-9.5. The data were analyzed using the 2-pK constant capacitance model(CCM)a...
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This work studies the effect of NTMP (nitrilotris(methylenephosphonic acid))on the adsorption of Cu(II), Zn(II), and Cd(II)onto boehmite in the pH range 5-9.5. The data were analyzed using the 2-pK constant capacitance model(CCM)assuming ternary surface complex formation. Under stoichiometric conditions, NTMP is more effective for removing Cu(II)than Zn(II)from solution and the contribution of ternary surface complexes are important to model the adsorption of both metals. Under nonstoichiometric conditions and high surface loading with a Me(II)/NTMP ratio of 1:5, Cu(II)and Zn(II)adsorption is signifcantly suppressed. In the case of Cd(II)the free metal adsorption is the most dominant species.
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Background Maternal obesity is a growing health concern that has previously been associated with increased need for induction of labour ( IOL ) and caesarean section ( CS ) rates. Currently, limited evidence explores the influence...
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Background Maternal obesity is a growing health concern that has previously been associated with increased need for induction of labour ( IOL ) and caesarean section ( CS ) rates. Currently, limited evidence explores the influence of maternal body mass index ( BMI) on Bishop Score ( BS ) and outcome of IOL . This study hypothesises that maternal obesity will lead to a lower BS at presentation, higher rates of failed IOL , and increased CS rates. Aims To explore the influence of maternal obesity on BS and likelihood of failed IOL . Methods A retrospective cohort analysis was conducted of all live, term, singleton, cephalic deliveries initiated with IOL across normal BMI (18.00–24.99), overweight BMI (25.00–29.99), and obese BMI (>30.00) at the Townsville Hospital and Health Service ( THHS ) between July 2011 to June 2016. Student’s t ‐test, χ 2 test, and binary logistic regression were used for statistical analysis. BS and failed IOL , defined as CS with cervical dilatation < 3?cm, were the primary outcome measures. Delivery mode was the secondary outcome measure. Results A total of 1543 women were included, 678 with normal BMI , 370 with overweight BMI , and 495 with obese BMI . Obese women are more likely to have a low BS (<5) at presentation ( unadjusted odds ratio (OR) 1.5 (1.1–2.0), P? < ? 0.05), an increased rate of failed IOL (adjusted OR ( aOR ) 1.6 (1.0–2.5), P? < ? 0.05) and increased CS rate ( aOR 1.1 (1.0–1.9), P? < ? 0.05), compared to normal weight women. Conclusions Maternal obesity is associated with a lower BS , more difficult IOL process, and increased risk of failed IOL and CS.
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Der Beitrag untersucht die Einflussgrossen fur eine auf die Unterneh-mensrandbedingungen abgestimmte PPS-Konfiguration. Hierbei stehen die Aspekte logistische Produktionsstrategie (Auspragungen: Standardisieren, Segmentieren, Indi...
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Der Beitrag untersucht die Einflussgrossen fur eine auf die Unterneh-mensrandbedingungen abgestimmte PPS-Konfiguration. Hierbei stehen die Aspekte logistische Produktionsstrategie (Auspragungen: Standardisieren, Segmentieren, Individualisieren) sowie die Kopplungsart zwischen Planung und Steuerung (Auspragungen: Mittelwert, Mittelwert und Toleranz, Einzelwerte) sowie ihre Aufgabenverteilung im Vordergrund. Diese Grunduberlegungen bestimmen die Anforderungen an die eingesetzten ERP- und MES-Losungen.
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The kinetics and the equilibria of complex formation between Ni(II) and 1,25-dimethyl-1,4,7,10,13,16,19,22,25-nonaazapentacosane (Me(2)Octaen) have been investigated in aqueous solution between pH 3 and 4.5 by the stopped-flow met...
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The kinetics and the equilibria of complex formation between Ni(II) and 1,25-dimethyl-1,4,7,10,13,16,19,22,25-nonaazapentacosane (Me(2)Octaen) have been investigated in aqueous solution between pH 3 and 4.5 by the stopped-flow method and UV spectrometry. Me(2)Octaen is a linear polyamine made by the union of eight en units bearing two methyl residues at the ends of the chain. Spectrophotometric titrations and kinetic experiments indicated that below pH 4.5 the binding of Ni(II) to the ligand gives rise to several 1:1 complexes differing in their degree of protonation, whereas above pH 4.5 binuclear complexes are formed as well. Concerning the mononuclear species, the ratios of the formation to the dissociation rate constants are in agreement with the equilibrium constants measured by static spectrometry. The analysis of the kinetic data reveals that the mostly reactive form of the ligand (denoted in its fully protonated form as H9L9+) is H5L5+, whereas the much more abundant species H6L6+ yields only a minor contribution to the overall process of complex formation. Measurements at different ionic strengths have shown positive salt effects, as expected for reactive processes involving particles with charges of the same sign. Addition of sodium acetate resulted in a large enhancement of the rate of the complex formation reaction, whereas the complex dissociation rate was found to be almost insensitive to the presence of the buffer. Analogous, although more modest, effects have been found with sodium chloroacetate. This behaviour is explained by assuming that the anion of the buffer could bind to Ni2+ and/or to the ligand, thus reducing the repulsion between the positively charged reaction partners. (C) 2000 Elsevier Science B.V. All rights reserved. [References: 17]
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The ability of mitochondria to take up Ca(2+) was discovered 50 years ago. This calcium uptake, through a mitochondrial calcium uniporter (MCU), is important not only for the regulation of cellular ATP concentration but also for m...
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The ability of mitochondria to take up Ca(2+) was discovered 50 years ago. This calcium uptake, through a mitochondrial calcium uniporter (MCU), is important not only for the regulation of cellular ATP concentration but also for more complex pathways such as shaping Ca(2+) signals and the activation of programmed cell death. The molecular nature of the uniporter remained unknown for decades. By a comparative study of mitochondrial protein profiles of organisms lacking or possessing MCU, such as yeast in the former case and vertebrates and trypanosomes in the latter, two groups recently found the protein that possesses all the characteristics of the MCU. These results add another success story to the already substantial contributions of trypanosomes to mammalian biochemistry. Copyright Copyright 2011 Elsevier Ltd. All rights reserved.
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Abstract Background How a woman gives birth can affect her health‐related quality of life ( HRQ oL). This study explored HRQ oL at 3?months postpartum in women with a history of one previous cesarean in three European countries. ...
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Abstract Background How a woman gives birth can affect her health‐related quality of life ( HRQ oL). This study explored HRQ oL at 3?months postpartum in women with a history of one previous cesarean in three European countries. Methods A prospective longitudinal survey, embedded within a cluster randomized trial in three countries, exploring women's postnatal HRQ oL up to 3?months postpartum. The Short‐Form Six‐Dimensions ( SF ‐6D) was used to measure HRQ oL, and multivariate analyses were used to examine the relationship with mode of birth. Results Complete data were available from 880 women. Women with a spontaneous vaginal birth had the highest HRQ oL scores, whereas women with an emergency repeat cesarean ( P ?=?.01) had the lowest. Postnatal readmission of the mother ( P ?=?.03), having public health insurance ( P ?=?.04), and a low antenatal HRQ oL score ( P ?<?.01) contributes to poorer HRQ oL scores. More specifically, women with a spontaneous vaginal birth had significantly higher HRQ oL scores on the vitality dimension compared with women with an emergency repeat cesarean ( P ?=?.04). Conclusions In women with low‐risk factors, repeat cesareans result in a poorer HRQ oL compared with vaginal birth. When there are no contraindications for vaginal birth, women with a history of one previous cesarean should be encouraged to give birth vaginally rather than have an elective repeat cesarean.
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Nitric oxide metabolism in plant cells has a relative short history. Nitration is a chemical process which consists of introducing a nitro group (-NO(2)) into a chemical compound. In biological systems, this process has been found...
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Nitric oxide metabolism in plant cells has a relative short history. Nitration is a chemical process which consists of introducing a nitro group (-NO(2)) into a chemical compound. In biological systems, this process has been found in different molecules such as proteins, lipids and nucleic acids that can affect its function. This mini-review offers an overview of this process with special emphasis on protein tyrosine nitration in plants and its involvement in the process of nitrosative stress. [References: 59]
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The ER (endoplasmic reticulum) has long been considered the plant cell compartment within which protein disulfide bond formation occurs. Members of the ER-located PDI (protein disulfide isomerase) family are responsible for oxidiz...
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The ER (endoplasmic reticulum) has long been considered the plant cell compartment within which protein disulfide bond formation occurs. Members of the ER-located PDI (protein disulfide isomerase) family are responsible for oxidizing, reducing and isomerizing disulfide bonds, as well as functioning as chaperones to newly synthesized proteins. In the present study we demonstrate that an abundant 7S lectin of the castor oil seed protein storage vacuole, RCA (Ricinus communis agglutinin 1), is folded in the ER as disulfide bonded A-B dimers in both vegetative cells of tobacco leaf and in castor oil seed endosperm, but that these assemble into (A-B)2 disulfide-bonded tetramers only after Golgi-mediated delivery to the storage vacuoles in the producing endosperm tissue. These observations reveal an alternative and novel site conducive for disulfide bond formation in plant cells.
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