摘要 : A series of previously unreported (2Z)-2-(lH-indol-l-yl)-3-(4-substituted phenyl)-l-phenylprop-2-en-l-one (5a -d) have been synthesized from easily accessible 2-(lH-indol-l-yl)-l-phenylethanone (3), which was obtained via a reacti... 展开 A series of previously unreported (2Z)-2-(lH-indol-l-yl)-3-(4-substituted phenyl)-l-phenylprop-2-en-l-one (5a -d) have been synthesized from easily accessible 2-(lH-indol-l-yl)-l-phenylethanone (3), which was obtained via a reaction of indole (1) with chloromethylphenyl ketone (2). The structures of the synthesized products have been elucidated using IR, 'H NMR, and mass-spectroscopic data and elemental analyses. The final products were screened for their antimicrobial activity. Excellent results were obtained against both bacteria and fungi. In conclusion, we have developed a novel, convenient and simple method for the preparation of indole - chalcone hybrid compounds via the reaction of indole derivative with carbonyl compounds in the presence of a strong base. The rapid conversion, excellent yield, utilization of a base, and operational simplicity are great advantages of the proposed method. 收起