摘要 : The present study was conducted to study genotoxic effect of excessive exposure to cadmium, lead and their mixture in Wistar rats. Sixty colony bred albino Wistar rats were divided randomly into five groups. The rats of group I re... 展开 The present study was conducted to study genotoxic effect of excessive exposure to cadmium, lead and their mixture in Wistar rats. Sixty colony bred albino Wistar rats were divided randomly into five groups. The rats of group I received only deionisedwater and served as negative control while, group II, III and IV were orally gavaged with cadmium chloride @ lOOppm; lead acetate @ 500 ppm; and mixture of cadmium chloride @ lOOppm & lead acetate @ 500ppm respectively for 28 days. Group V was kept as apositive control, and was given cycophosphamide (20 mg/kg body weight i.p. 24 hours prior to terminal sacrifice). All the three treatment groups showed significant (PO.05) increase in micronuclei as compared to negative control. The findings of the micronuclei study suggested that cadmium and lead when administered alone were equally genotoxic to that of mixture of both the metals at the given dose level however their genotoxic potential was less than the positive control. 收起