摘要 : Eight months after BNT162b2 vaccination neutralizing activity declined 2- to 3.7-fold for all VoC and 19% of naive individuals lacked neutralizing activity against SARS-CoV-2 delta variant. In convalescent vaccinated individuals h... 展开 Eight months after BNT162b2 vaccination neutralizing activity declined 2- to 3.7-fold for all VoC and 19% of naive individuals lacked neutralizing activity against SARS-CoV-2 delta variant. In convalescent vaccinated individuals high initial humoral response resulted in detectable neutralization against all VoC. We have investigated the evolution of the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at 8 months after Pfizer-BNT162b2 vaccination in coronavirus disease 2019 (COVID-19)-naive (n = 21) and COVID-19-convalescent (n = 21) individuals. Neutralizing levels declined for all variants (range 2- to 3.7-fold). Eight months after vaccination, a significant proportion (4/21) of naive individuals lacked detectable neutralizing activity against the highly transmissible SARS-CoV-2 delta variant. In the convalescent group, the impressive high initial humoral response resulted in detectable neutralizing antibody levels against all variants throughout this period. 收起