摘要 : The Letter to the Editor send by Drs. Ayra and Nirmala [ 1 ] rightly points out that the absence of IgM might increase the chances of a secondary or a dengue vaccine-linked disease transmission through the mosquito bite. We would ... 展开 The Letter to the Editor send by Drs. Ayra and Nirmala [ 1 ] rightly points out that the absence of IgM might increase the chances of a secondary or a dengue vaccine-linked disease transmission through the mosquito bite. We would like to provide additional observations concerning IgM seropositivity and clinical outcome. In our previous report, we found a correlation between high seropositivity rate to IgM and low viral load levels. Thus, we have concluded that IgM seropositivity may interfere with viral detection and may be related with a better infection control by the host [2]. Therefore, we analyzed if there is a correlation between IgM seropositivity and dengue disease clinical outcome using a panel of 380 sera from dengue patients collected within the first 5 days after fever onset. Most of the infections (83.1%) corresponded to primary cases. 收起