摘要 : We investigated the anti-inflammatory effects of ethyl pyruvate (EP) on LPS-stimulated canine PBMCs <i>in vitro</i>. We found that EP treatment inhibited the mRNA expressions of proinflammatory cytokines (TNF- alpha and IL-6), but... 展开 We investigated the anti-inflammatory effects of ethyl pyruvate (EP) on LPS-stimulated canine PBMCs <i>in vitro</i>. We found that EP treatment inhibited the mRNA expressions of proinflammatory cytokines (TNF- alpha and IL-6), but induced mRNA expression of anti-inflammatory cytokines (IL-10). ELISA measurements revealed that EP also effectively downregulates the LPS-induced increase in proinflammatory cytokine release, while upregulating anti-inflammatory cytokine release. These data indicate that EP could be an effective anti-inflammatory agent in dogs. 收起