摘要 : Auditory nerve (AN) fibers that innervate inner hair cells in the cochlea degenerate with advancing age. It has been proposed that age -related reductions in brainstem frequency -following responses (FFR) to the carrier of low -fr... 展开 Auditory nerve (AN) fibers that innervate inner hair cells in the cochlea degenerate with advancing age. It has been proposed that age -related reductions in brainstem frequency -following responses (FFR) to the carrier of low -frequency, high -intensity pure tones may partially reflect this neural loss in the cochlea (Ma <spacing diaeresis>rcher-R & oslash; rsted et al., 2022). If the loss of AN fibers is the primary factor contributing to age -related changes in the brainstem FFR, then the FFR could serve as an indicator of cochlear neural degeneration. In this study, we employed electrocochleography (ECochG) to investigate the effects of age on frequency -following neurophonic potentials, i.e., neural responses phase -locked to the carrier frequency of the tone stimulus. We compared these findings to the brainstem-generated FFRs obtained simultaneously using the same stimulation. We conducted recordings in young and older individuals with normal hearing. Responses to pure tones (250 ms, 516 and 1086 Hz, 85 dB SPL) and clicks were recorded using both ECochG at the tympanic membrane and traditional scalp electroencephalographic (EEG) recordings of the FFR. Distortion product otoacoustic emissions (DPOAE) were also collected. In the ECochG recordings, sustained AN neurophonic (ANN) responses to tonal stimulation, as well as the click -evoked compound action potential (CAP) of the AN, were significantly reduced in the older listeners compared to young controls, despite normal audiometric thresholds. In the EEG recordings, brainstem FFRs to the same tone stimulation were also diminished in the older participants. Unlike the reduced AN CAP response, the transient -evoked wave -V remained unaffected. These findings could indicate that a decreased number of AN fibers contributes to the response in the older participants. The results suggest that the scalp -recorded FFR, as opposed to the clinical standard wave -V of the auditory brainstem response, may serve as a more reliable indicator of age -related cochlear neural degeneration. 收起