摘要 : Many mechanistic studies have been performed to analyze the cellular functions of the highly phosphorylated molecule inositol hexakisphosphate (InsP(6)) in health and disease. While the physiological intracellular functions are we... 展开 Many mechanistic studies have been performed to analyze the cellular functions of the highly phosphorylated molecule inositol hexakisphosphate (InsP(6)) in health and disease. While the physiological intracellular functions are well described, the mechanism of potential pharmacological effects on cancer cell proliferation is still controversial. There are numerous studies demonstrating that a high InsP(6) concentration (>= 75 mu M) inhibits growth of cancer cells in vitro and in vivo. Thus, there is no doubt that InsP(6) exhibits anticancer activity but the mechanism underlying the cellular effects of extracellular InsP(6) on cancer cells is far from being understood. In addition, studies on the inhibitory effect of InsP(6) on cancer progression in animal models ignore aspects of its bioavailability. 收起