摘要 : Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and abnormal aggregates of alpha-synuclein protein called Lewy bodies. To date, there is no drug that can definite... 展开 Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and abnormal aggregates of alpha-synuclein protein called Lewy bodies. To date, there is no drug that can definitely slow down or stop the progression of this disease. The discovery of the cell-to-cell transmission of pathologic alpha-synuclein seeds offers the possibility to explore novel treatment strategies to prevent the spread of alpha-synuclein, with the purpose of slowing down the progression of PD in its tracks. Although recent studies have made tremendous progress in understanding how alpha-synuclein spreads throughout the brain, neuroinflammation seems to play a crucial role in the development of alpha-synuclein pathology in PD. The activation of microglia, one of the hallmarks of the neuroinflammatory process, is suggested to influence the neuron-to-neuron transmission of alpha-synuclein. This review summarizes how activated microglia facilitate this process, and focuses on the following mechanisms including the activation of microglia in PD, the reduced ability of activated microglia to clear alpha-synuclein and increased migratory capacity of microglia in PD, as well as the cooperation between microglia and exosomes in mediating alpha-synuclein release and propagation. In conclusion, this article help collate information on microglia in-relation to PD. 收起