摘要 : Background: Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-L-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human stu... 展开 Background: Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-L-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human studies of GI injury. Hypothesis: The combination of zinc-L-carnosine and vitamin E attenuates aspirin-induced gastroduodenal mucosal injury. Animals: Eighteen healthy random-source Foxhound dogs. Methods: In this randomized, double-blinded, placebo-controlled study dogs were treated with placebo (n=6; 0X group), 30 mg/30 IU (n=6; 1X group), or 60 mg/60 IU (n=6; 2X group) zinc-L-carnosine/vitamin E orally every 12 hours for 35 days. Between Day 7 and 35, GI mucosal lesions were induced with aspirin (25 mg/kg PO q8h). Mucosal injury lesions (hemorrhage, erosion, and ulcer) were assessed by gastroduodenoscopy on Days 14, 21, and 35 with a 12-point scoring scale. Results: At baseline (Day -1) gastroscopy scores were not significantly different between groups (mean+or-SD: 0X, 4.4+or-0.8; group 1X, 4.4+or-0.6; group 2X, 4.2+or-0.3; <i>P</i>=.55). Gastroscopy scores increased significantly in all groups between Day -1 and Days 14, 21, and 35 (<i>P</i><.0001). On Day 35, gastroscopy scores were 29.2+or-5.2 (0X), 27.3+or-3.7 (1X), and 28.6+or-3.3 (2X). Mean gastroscopy scores were not significantly different among treatment groups on any of the days (<i>P</i>=.61). Conclusions and Clinical Importance: Administration of the combination of zinc-L-carnosine and vitamin E at 1X or 2X dosing did not attenuate aspirin-induced gastroduodenal mucosal injury. 收起