摘要 : Schiffbases and benzimidazoles compounds exhibit an extensive range of therapeutic applications, such as anticancer agents. The present study shows the synthesis of the 2-(4-methoxyphenyl)1H-benzimidazole hydrochloride (BenzHCl) f... 展开 Schiffbases and benzimidazoles compounds exhibit an extensive range of therapeutic applications, such as anticancer agents. The present study shows the synthesis of the 2-(4-methoxyphenyl)1H-benzimidazole hydrochloride (BenzHCl) from N,N'-bis-(4-methoxybenzylidene)-benzene-1,2-diamine (Anisalophen) mediated by chloride lanthanide (Gd3+, Tb3+, or Eu3+). The mechanism of the reaction is proposed from different synthetic strategies. BenzHCl crystallizes in the monoclinic system, space group P2(1) and shows the iminic nitrogen atom protonated, which is stabilized by the chlorine ion. BenzHCl and Anisalophen were characterized, and their thermal stabilities were analyzed by TG/DTA techniques. Anisalophen and BenzHCl showed higher cytotoxic activity against human breast cancer cells (MCF-7 and MDA-MB-231) when compared to human fibroblast cells. (C) 2021 Elsevier B.V. All rights reserved. 收起