摘要 : Multiple cytokines released in tumor microenvironment can promote anticancer effects, or carcinogenesis and tumor growth. Although cytokines mainly act locally, the changes in their circulating levels may reflect the interactions ... 展开 Multiple cytokines released in tumor microenvironment can promote anticancer effects, or carcinogenesis and tumor growth. Although cytokines mainly act locally, the changes in their circulating levels may reflect the interactions between tumor and inflammatory cells during the disease course. The aim of this study was to analyze the serum cytokine profile in patients with differentiated thyroid cancer (DTC) and to identify cytokines those could be associated with tumor progression/metastasis. Serum concentrations of thirteen cytokines were measured in control subjects and DTC patients before, three and seven days after radioactive iodine therapy, using multiplex cytokine detection systems for Thl/Th2/Th9/Th17/Th22 cell-related cytokines Most cytokines were not detected in serum samples from control subjects, while detectable levels of the cytokines were measured in some, but not all DTC patients. The serum levels of the following cytokines: interleukin IL-17A, IL-10 and IL-13 were significantly increased in DTC patients with metastasis. At the same time, the concentrations of several cytokines (IL-12p70, IL-17A, IL-5, IL-1p and tumor necrosis factor (TNF-alpha) were positively correlated with thyroglobulin (Tg) levels. The histological type of tumor, hypothyroidism, and intensity of oxidative stress were not associated with cytokine levels in patients' sera. Radioactive 131-I therapy reduced serum levels of the majority of examined cytokines, but these differences did not reach statistical significance. In conclusion, the study indicates that the increase of the levels of several Th2/Th17 cells and proinflammatory cytokines in the serum of patients with DTC is associated with tumor progression/metastasis. Thus, the increase in this specific cytokine constellation might be an indicator of the malignant disease progression. 收起