摘要 : The epitope on NS3 recognized by dengue 2 virus serotype-cross-reactive CD4+ CD8- T cell clones (JK36 and JK46) was mapped. These CD4+ CTL clones recognized dengue 2, dengue 3 and dengue 4 viruses, but did not recognize dengue 1. ... 展开 The epitope on NS3 recognized by dengue 2 virus serotype-cross-reactive CD4+ CD8- T cell clones (JK36 and JK46) was mapped. These CD4+ CTL clones recognized dengue 2, dengue 3 and dengue 4 viruses, but did not recognize dengue 1. The minimum recognition unit of the epitope recognized by JK36 was 8 amino acids in length and was located between amino acids 226 and 233 of dengue 2, dengue 3 and dengue 4 viruses. The epitope recognized by JK46 consisted of 11 amino acids and was located between amino acids 224 and 234. Results of experiments to determine HLA-restriction in the recognition of the epitope suggested that JK36 and JK46 are HLA-DR15-restricted. 收起