摘要 : In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR-143-3p and miR-143-5p are the mature miRNAs derived from pre-miRNA-143. At pres... 展开 In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR-143-3p and miR-143-5p are the mature miRNAs derived from pre-miRNA-143. At present, there are numerous studies on the function of miR-143-3p in cancer progression, but there are no systematic reviews describing the function of miR-143-3p in cancer. It is widely considered that miR-143-3p is downregulated in most malignant tumors and that upstream regulators can act on this gene, which in turn regulates the corresponding target to act on the tumor. In addition, miRNA-143-3p can regulate target genes to affect the biological process of tumors through various signaling pathways, such as the PI3K/Akt, Wnt/beta-catenin, AKT/STAT3 and Ras-Raf-MEK-ERK pathways. The present review comprehensively described the biogenesis of miR-143-3p, the biological functions of miR-143-3p and the related roles and mechanisms in different cancer types. The potential of miR-143-3p as a biomarker for cancer was also highlighted and valuable future research directions were discussed. 收起