摘要 : Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquin... 展开 Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquinone-binding sites in enzymes of the electron-transport chain. Interestingly, even minor structural changes in related N-oxides produced by the same organism can produce a dramatic difference in antibiotic activity, suggesting possible functional specialization. 收起