摘要 : Three esters of rhodamine B (1-3) differing in their alkyl chain lengths as well as several rhodamine B amides (4-9) were synthesized in good yields and tested for their cytotoxicity in SRB assays employing several human tumor cel... 展开 Three esters of rhodamine B (1-3) differing in their alkyl chain lengths as well as several rhodamine B amides (4-9) were synthesized in good yields and tested for their cytotoxicity in SRB assays employing several human tumor cell lines. The rhodamine B esters were unselective but showed cytotoxicity of as low as EC50 = 0.15 +/- 0.02 mu M. The rhodamine B amides were slightly less cytotoxic but showed good selectivity against MCF-7 and A2780 tumor cell lines. Especially a morpholinyl derivative4was similar to 20 time more cytotoxic for MCF-7 than for nonmalignant NIH 3T3 cells. 收起