摘要 : Objective?The aim of this study is to examine the association of breastfeeding with metabolic syndrome (MetS) in women with recent gestational diabetes mellitus (GDM) in the very early postpartum (PP) period. Study Design?We perfo... 展开 Objective?The aim of this study is to examine the association of breastfeeding with metabolic syndrome (MetS) in women with recent gestational diabetes mellitus (GDM) in the very early postpartum (PP) period. Study Design?We performed a secondary analysis of the Balance After Baby Intervention (BABI) study which enrolled women with recent GDM. Data collected during an early (~8 weeks) PP visit were used in this analysis. At this visit, weight, height, waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG), and lipids were obtained. MetS was classified per National Cholesterol Education Program Adult Treatment Program III (NCEP-ATP III) criteria. We defined breastfeeding as currently breastfeeding or not currently breastfeeding for the main analysis. Results?Of 181 women enrolled in BABI, 178 were included in this analysis (3 excluded for missing lipids). Thirty-four percent were Hispanic. Of non-Hispanics, 31.5% were White, 18.5% Asian, and 12.9% Black/African American. The prevalence of MetS was 42.9% in women not breastfeeding versus 17.1% in women breastfeeding (p?<?0.001; adjusted odds ratio [aOR]?=?0.16 [95% confidence interval (CI): 0.06–0.41]). Breastfeeding women had significantly lower odds of FPG ≥100?mg/dL (aOR?=?0.36 [95% CI: 0.14–0.95], p?=?0.039), HDL?<?50?mg/dL (aOR?=?0.19 [95% CI: 0.08–0.46], p?<?0.001), and triglycerides (TG) ≥ 150?mg/dL (aOR?=?0.26 [95% CI: 0.10–0.66], p?=?0.005). When evaluated as continuous variables, WC, FPG, and TG were significantly lower and HDL significantly higher in women breastfeeding in the very early PP period (vs. not breastfeeding). Conclusion?In a diverse population of women with recent GDM, there was lower prevalence of MetS in women breastfeeding compared with those not breastfeeding in the very early PP period. This study extends the findings of an association of breastfeeding with MetS previously reported at time points more remote from pregnancy to the very early PP period and to an ethnically and racially diverse population. Key Points MetS prevalence in women with recent GDM was lower in breastfeeding than not breastfeeding women. FPG, HDL, WC, and TG were improved in the breastfeeding group. This study extends prior findings to the very early PP period and to a diverse population. 收起