摘要 : Background: The measurement and detection of viremia and antigenemia in sera have been used as a marker of risk for dengue disease severity and diagnosis. However, evidence exists suggesting that levels of viremia and antigenemia ... 展开 Background: The measurement and detection of viremia and antigenemia in sera have been used as a marker of risk for dengue disease severity and diagnosis. However, evidence exists suggesting that levels of viremia and antigenemia are affected by the presence of specific antibodies. Objective: To compare viral load and circulating NS1 levels in sera from patients positive or negative for dengue specific IgM antibodies. Study design: Three hundred and eighty serum samples were analyzed for viral load using qRT-PCR and for levels of circulating NS1 and the presence of specific antibodies using commercial EIAs. Results and conclusion: Comparison of viremia levels in sera from patients positive or negative for dengue IgM antibodies showed that viral load was significantly higher ( p≤. 0.0001) in patients negative for IgM antibodies. In contrast, levels of circulating NS1 were found unaffected by the presence of IgM ( p= 0.0038). Thus, dengue virus specific IgM antibodies in sera seem to be a strong negative modulator of viremia levels in patient's sera. 收起