摘要 : Pestalofones I - K (1-3), three new dimeric meroterpenoids with 2-(7-benzoyl-2,3-dihydrobenzofuran-2-yl)-1-phenylethan-1-one (in 1) and 2-(7-benzoyl-2,3-dihydrobenzofuran-2-yl)-1-(3,8-dioxatricyclo[5.1.0.0(2,4)]oct-4-yl)ethan-1-on... 展开 Pestalofones I - K (1-3), three new dimeric meroterpenoids with 2-(7-benzoyl-2,3-dihydrobenzofuran-2-yl)-1-phenylethan-1-one (in 1) and 2-(7-benzoyl-2,3-dihydrobenzofuran-2-yl)-1-(3,8-dioxatricyclo[5.1.0.0(2,4)]oct-4-yl)ethan-1-one (in 2 and 3) skeletons, were isolated from the solid cultures of the plant endophytic fungus Pestalotiopsis fici. The structures of 1-3 were elucidated by NMR experiments. Compound 1 was found to be present as a racemic mixture. The absolute configurations of 2 and 3 were deduced by analogy to the previously isolated metabolites pestalofones G and H (4 and 5) from the same fungus. Biogenetically, compounds 1-3 are derived from the same precursors (co-isolated compounds 9 and 10) as the previously isolated compounds 4-8. Compounds 2 and 3 showed weak cytotoxic activities against four human tumor cell lines T24, HeLa, A549, and MCF-7. 收起