摘要 : Despite considering hypofractionated radiotherapy (HRT) a useful treatment option for feline localized sinonasal lym-phoma (stage I), the benefits of additional chemotherapy remain controversial. This retrospective cohort study ev... 展开 Despite considering hypofractionated radiotherapy (HRT) a useful treatment option for feline localized sinonasal lym-phoma (stage I), the benefits of additional chemotherapy remain controversial. This retrospective cohort study evaluated the efficacy of the early initiation of chemotherapy in combination with HRT (HRTC) to prolong the progression-free sur-vival (PFS) and overall survival (OS) in cats with localized sinonasal lymphoma compared with HRT alone. While 24 eligi-ble cats received HRT alone (HRT group), 18 received HRTC (HRTC group). The total median administered dose was 35 Gy, with one fraction per week, for a median of five fractions. In the HRTC group, the chemotherapy protocol was cyclo-phosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-based and cyclophosphamide, vincristine, and prednis-olone (COP)-based in 14 (78%) and 4 cats (22%), respectively. Cats in the HRTC group had significantly longer PFS (677 versus 104 days; P = .04) and OS (983 versus 263 days; P = .04) than those in the HRT group. Considering the poor out-come in the HRT group despite the cats having received rescue chemotherapy for progressive disease, the early initia-tion of additional chemotherapy along with HRT may be recommended for feline localized sinonasal lymphoma. (J Am Anim Hosp Assoc 2022; 58:254-261. DOI 10.5326/JAAHA-MS-7267) 收起