摘要 : New Furan, 1,3,4-thiadiazole and 1,2,4-triazole hybrid compounds and their 1,3,4-oxadiazole hybrid derivatives were synthesized. The thioglycoside derivatives of the synthesized hybrid compounds were synthesized via glycosylation ... 展开 New Furan, 1,3,4-thiadiazole and 1,2,4-triazole hybrid compounds and their 1,3,4-oxadiazole hybrid derivatives were synthesized. The thioglycoside derivatives of the synthesized hybrid compounds were synthesized via glycosylation of the triazole-5-thione and 1,3,4-oxadiazole-5-thione derivatives. The hydrazinyl sugar derivative of the thiadiazole system and hydroxyalkylamino derivative of the 1,2,4-triazole compound were also prepared. The cytotoxic activities of the synthesized compounds were studied against MCF-7 (human breast adenocarcinoma) cancer cell and RPE-1 (human normal Retina pigmented epithelium) cell lines using the MTT assay. The obtained results showed that a number of the synthesized compounds revealed good activities comparable to that observed for the reference drug doxorubicin against the MCF-7 cancer cell lines. 收起