摘要 : The synthesis and characterisation of new anionic iridium(II) complexes (NH4)(2)[IrCl4(kappa N-2,N'-H(2)biim)](2) center dot 5H(2)O (1) and ((CH3)(2)NH2)[IrCl4(kappa N-2,N'-PyBIm)] center dot H2O (2) are presented in this article.... 展开 The synthesis and characterisation of new anionic iridium(II) complexes (NH4)(2)[IrCl4(kappa N-2,N'-H(2)biim)](2) center dot 5H(2)O (1) and ((CH3)(2)NH2)[IrCl4(kappa N-2,N'-PyBIm)] center dot H2O (2) are presented in this article. Spectroscopic methods (H-1, C-13 and N-15 NMR, FTIR, UV-Vis) were used to characterize these new complexes. Solid-state structural analysis (SC-XRD) of complexes 1 and 2 shows a slightly distorted octahedral geometry of Ir(III) ions, which is constructed by one chelating kappa 2N,N'-2,2'-biimidazole (H2biim (1)) or 2-(2'-pyridyl)benzimidazole (PyBIm (2)) and four chloride ions. In the crystal structures, the presence of organic ligands containing NH groups favours the formation of strong hydrogen bonds (XH center dot center dot center dot Cl (X = O, N, C)), which have significant impact on the crystal structure forming 2D (1) and 3D (2) systems during the self-assembly process. Additionally, preliminary studies of the biological activity of the obtained complexes were performed. Considering the above properties, the observed stronger binding affinity of complex 1 to DNA and HSA can be interpreted in terms of changes in the number of hydrogen bonds that are potentially formed with the target molecule. Furthermore, higher reactivity towards NADH and the lower reactivity towards GSH were observed for complex 2. Both complexes showed moderate cytotoxicity against selected cancer cell lines (LoVo, MV-4-11, MCF-7) and did not show toxicity towards normal cells (BALB/3T3). The cytotoxicity of 2 may be compromised by a weaker interaction with DNA, HSA or GSH and a stronger reactivity towards NADH. 收起