摘要 : ? 2022The liver vasculature is unique with a dual blood supply and consists of four separate systems: the portal veins, hepatic arteries, hepatic veins, and hepatic sinusoids. Multiple disorders can affect each of these components... 展开 ? 2022The liver vasculature is unique with a dual blood supply and consists of four separate systems: the portal veins, hepatic arteries, hepatic veins, and hepatic sinusoids. Multiple disorders can affect each of these components with very diverse clinical presentations ranging from subclinical to acute liver failure. In many of the cases the diagnosis is made clinically, and biopsies are reserved for cases with an atypical presentation, unclear diagnosis or for the evaluation of a concomitant underlying liver disease. The histologic features of these conditions are often subtle and easily overlooked and requires a systematic evaluation. In this review, the disorders affecting the liver vasculature are discussed based on the major vascular system involved. In addition, noncirrhotic portal hypertension, which is thought to be secondary to abnormal hemodynamics largely due to the involvement of the terminal portal venules is also discussed. In each section the key histologic and clinical features are described. Awareness of the diverse histologic findings seen in these conditions and developing a systematic approach when evaluating liver biopsies will ultimately aid pathologists in their clinical practice to better understand and diagnose these challenging disorders. 收起