摘要 : Changes in concentration (0.001-0.1 M) of an arabinofuranosyl donor (1) have been shown to modulate the temperature Tat which activation of I occurs (from -23 degrees C to +7 degrees C), the reaction time (from 1.5 h to 3 days) an... 展开 Changes in concentration (0.001-0.1 M) of an arabinofuranosyl donor (1) have been shown to modulate the temperature Tat which activation of I occurs (from -23 degrees C to +7 degrees C), the reaction time (from 1.5 h to 3 days) and the yield of the disaccharide formed (from 14% to 82%). At concentrations- exceeding 0.01 M, these parameters, as well as the specific optical rotation of the solution of I, virtually do not depend on concentration suggesting formation of reacting species (supramers) of glycosyl donor with similar structures, hence reactivities, but considerably different from those formed in more dilute solutions. The found critical concentration (0.01 M) separates two concentration ranges of reaction solutions corresponding to two types of solution structure that are'featured by the presence of fundamentally different supramers of glycosyl donor, which have distinct chemical properties. These results allow a fresh look at the problems of reactivity of chemical compounds and selectivity of the reactions in which they participate. (C) 2016 Elsevier Ltd. All rights reserved. 收起