摘要 : A novel nor-phragmalin-type limonoid,named carapanosin D(1),and two novel mexicanolide-type limonoids,carapanosins E(2)and F(3),were isolated from the seed oil of andiroba(Carapa guianensis A_(ublet)),a traditional medicine in Bra... 展开 A novel nor-phragmalin-type limonoid,named carapanosin D(1),and two novel mexicanolide-type limonoids,carapanosins E(2)and F(3),were isolated from the seed oil of andiroba(Carapa guianensis A_(ublet)),a traditional medicine in Brazil and Latin American countries.Their structures were unambiguously determined on the basis of spectroscopic analyses using one-dimensional(1D)and two-dimensional(2D)NMR techniques and High resolution Fast Atom Bombardment Mass Spectrometry(HRFABMS).Compounds 1-3 were evaluated for their effects on the production of nitric oxide(NO)in Lipopolysaccharide(LPS)-activated mouse peritoneal macrophages.The NO inhibitory assay suggested that compounds 2 and 3 have high potency as inhibitors of macrophage activation. 收起