摘要: The main goal of our USAMRMC project was to develop a new concept in diagnostic imaging of breast cancer, laser optoacoustic imaging system (LOTS) . The major effort during the 1 Year project was made on system modeling, design, a... 展开 The main goal of our USAMRMC project was to develop a new concept in diagnostic imaging of breast cancer, laser optoacoustic imaging system (LOTS) . The major effort during the 1 Year project was made on system modeling, design, and fabrication of system hardware and development of the system software. The test results demonstrated that utilization of optical tissue contrast produces significant advance in quality of ultrasound images. All research aims were accomplished yielding a clinical prototype of two-dimensional optoacoustic imaging system with parameters exceeding those of existing ultrasound systems: tissue contrast 250-600%, sensitivity 5 V/bar, effective noise 4 micro-bar, and resolution of 0.5 mm x 1 mm. After thorough tests in gel phantoms resembling optical and acoustic properties of the breast, LOTS performance was evaluated ex-vivo in mastectomy specimens with ductal carcinoma. The results demonstrated that LOIS produces high-resolution images with significantly enhanced contrast between tumors and normal tissues yielding resolution similar to that of digital ultrasound imaging. 收起