摘要 : Reserpine is an indole alkaloid obtained from the root ofRauwolfia serpentine (Gates 1996). It is prescribed in humanmedicine to treat high blood pressure and calm severelyagitated mental health patients and acts by decreasing hea... 展开 Reserpine is an indole alkaloid obtained from the root ofRauwolfia serpentine (Gates 1996). It is prescribed in humanmedicine to treat high blood pressure and calm severelyagitated mental health patients and acts by decreasing heartrate, decreasing cardiac contractility and relaxing blood vessels(Benowitz 1995). Reserpine is not approved for use in horses;nevertheless, this drug is sometimes administered forprolonged tranquilisation. Reserpine has also been reporteduseful for treatment of agalactia in mares associated withfescue toxicosis, although the current treatment of choice isdomperidone, a DA2 dopamine receptor antagonist that doesnot cross the blood-brain barrier, thus resulting in fewer sideeffects (Evans ef al. 1999). 收起