摘要 : The transmission and pathogenesis of highly contagious fatal respiratoryviruses are increasing, and the need for an on-site diagnostic platform hasarisen as an issue worldwide. Furthermore, as the spread of respiratoryviruses cont... 展开 The transmission and pathogenesis of highly contagious fatal respiratoryviruses are increasing, and the need for an on-site diagnostic platform hasarisen as an issue worldwide. Furthermore, as the spread of respiratoryviruses continues, different variants have become the dominant circulatingstrains. To prevent virus transmission, the development of highly sensitiveand accurate on-site diagnostic assays is urgently needed. Herein, a facilediagnostic device is presented for multi-detection based on the results ofdetailed receptor‒ligand dynamics simulations for the screening of variousviral strains. The novel bioreceptor-treated electronics (receptonics) deviceconsists of a multichannel graphene transistor and cell-entry receptorsconjugated to N-heterocyclic carbene (NHC). An ultrasensitive multi-detectionperformance is achieved without the need for sample pretreatment, which willenable rapid diagnosis and prevent the spread of pathogens. This platformcan be applied for the diagnosis of variants of concern in clinical respiratoryvirus samples and primate models. This multi-screening platform can be usedto enhance surveillance and discriminate emerging virus variants before theybecome a severe threat to public health. 收起