摘要 : In a recent article published in Cell Research,the structure of an array of 12 nucleosomes compacted to a 30-nm fiber reveals details about nucleosome-nucleosome interactions and the binding and folding of linker histone H5.In euk... 展开 In a recent article published in Cell Research,the structure of an array of 12 nucleosomes compacted to a 30-nm fiber reveals details about nucleosome-nucleosome interactions and the binding and folding of linker histone H5.In eukaryotes,genomic DNA is packaged into different levels of chromatin organization in the nucleus.The fundamental repeating unit of chromatin is called a nucleosome,consisting of the histone octamer and ca.15obp of DNA.Multiple nucleosomes are connected by segments of linker DNA,forming nucleosomal arrays with a 10-nm diameter and a‘beads-on-a-string''arrangement.Nucleosomal arrays were proposed to be further organized into a higher-order assembly by the linker histones,which have been shown to play a fundamental role in chromatin compaction.In a recent article published in Cell Research,Li et al."provide structural information on a nucleosome array containing 12 nucleosomes,bound to linker histone H5 and folded into a 30-nm fiber,revealing insights into the structure and mechanism of higher-order compaction. 收起