摘要 : Escaping the immune response is a major prerequisite for tumor to emerge and progress,and many different mechanisms are in place within the tumor microenvironment(TME)to reach this aim,including the induction of CD8^(+)T cell exha... 展开 Escaping the immune response is a major prerequisite for tumor to emerge and progress,and many different mechanisms are in place within the tumor microenvironment(TME)to reach this aim,including the induction of CD8^(+)T cell exhaustion.In a recent publication in Cell,Zhang and colleagues showed that biomechanical stress occurring in the TME enforces CD8^(+)T cell exhaustion through the expression of the transcription factor Osr2 that acts as an epigeneticregulator.First identified in chronic infection,exhausted CD8^(+)T cells express multiple inhibitory receptors,have reduced effector functions,and are not able to efficiently control pathogens or tumors.1The main inducer of exhaustion is the continuous triggering of the T cell receptor(TCR),2 but several factors present in the tumor microenvironment(TME)such as metabolite deprivation,high pH or hypoxia could further participate in the induction and maintenance of this program in a cancer-specific manner.3 The exhaustion program is established through the expression of several transcription factors(TFs)such as TOX. 收起