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In this study,four different-shaped G+9 storey RCC frame buildings were analyzed by STAAD.Pro.V8i (Series 6) for seismic Zone -II,Raipur,Chhattisgarh. Furthermore,the purpose of this study was to perform a response spectrum analys...
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In this study,four different-shaped G+9 storey RCC frame buildings were analyzed by STAAD.Pro.V8i (Series 6) for seismic Zone -II,Raipur,Chhattisgarh. Furthermore,the purpose of this study was to perform a response spectrum analysis (RSA) of four different shapes of RCC frame buildings by considering the same physical properties such as building area,beam dimensions,column dimensions,load calculations,seismic parameters,and material specifications. and makes every frame economical. Comparison of seismic parameters would allow us to propose the best building layout on the existing conditions. The research study focuses on the seismic analysis of various forms of the RCC frame building by varying the column size (outside and inside) as well as the carrier sizes (in floors) and to solve the problem of the maximum moved building by means of some retrofitting measures. The main goals of this project are to improve the quality of life for residents of this area,and to reduce crime in the area. More specifically,the salient objectives of this project are: ? To compare the seismic parameters such as story displacement,compressive stress of all frames and,? To improve the structure by providing different retrofitting’s in ideal location.
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Purpose: Vγ9Vδ2 (γδ) T lymphocytes, a critical peripheral blood lymphocyte subset, are directly cytotoxic against many solid and hematologic tumor types. Vγ9Vδ2 T lymphocytes can be selectively expanded in vivo with BrHPP (I...
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Purpose: Vγ9Vδ2 (γδ) T lymphocytes, a critical peripheral blood lymphocyte subset, are directly cytotoxic against many solid and hematologic tumor types. Vγ9Vδ2 T lymphocytes can be selectively expanded in vivo with BrHPP (IPH1101) and IL-2. The present phase I trial was conducted with the aim of determining the maximum-tolerated dose (MTD) and safety of IPH1101 combined with a low dose of IL-2 in patients with solid tumors. Experimental design: A 1-h intravenous infusion of IPH11 was administered alone at cycle 1, combined with a low dose of SC IL-2 (1 MIU/M 2 d1 to d7) in the subsequent cycles (day 1 every 3 weeks). The dose of IPH1101 was escalated from 200 to 1,800 mg/m2. Results: As much as 28 patients with solid tumors underwent a total of 109 treatment cycles. Pharmacodynamics data demonstrate that γδ T lymphocyte amplification in humans requires the co-administration of IL-2 and is dependent on IPH 1101 dose. Dose-limiting toxicity occurred in two patients at a dose of 1,800 mg/m2: one grade 3 fever (1 patient) and one grade 3 hypotension (1 patient) suggesting cytokine release syndrome immediately following the first infusion. At lower doses the treatment was well tolerated; the most frequent adverse events were mild fever, chills and abdominal pain, without exacerbation in the IL-2 combined cycles. Conclusion: IPH1101 in combination with SC low-dose IL-2 is safe, well tolerated and induces a potent γδ T lymphocyte expansion in patients. Its clinical activity will be evaluated in phase II clinical trials.
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Purpose Vγ9Vδ2 (γδ) T lymphocytes, a critical peripheral blood lymphocyte subset, are directly cytotoxic against many solid and hematologic tumor types. Vγ9Vδ2 T lymphocytes can be selectively expanded in vivo with BrHPP (IP...
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Purpose Vγ9Vδ2 (γδ) T lymphocytes, a critical peripheral blood lymphocyte subset, are directly cytotoxic against many solid and hematologic tumor types. Vγ9Vδ2 T lymphocytes can be selectively expanded in vivo with BrHPP (IPH1101) and IL-2. The present phase I trial was conducted with the aim of determining the maximum-tolerated dose (MTD) and safety of IPH1101 combined with a low dose of IL-2 in patients with solid tumors.
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Background. Patients contracting influenza A(H7N9) infection often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information on drug-resistance...
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Background. Patients contracting influenza A(H7N9) infection often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information on drug-resistance markers for influenza A(H7N9) is limited.
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Pattern and Group behavior of COVID-19 patient’s data is very much important aspect of data analysis for medical stakeholders to frame decision strategies and to design routine set-ups. PCA is old mathematical machine learning gr...
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Pattern and Group behavior of COVID-19 patient’s data is very much important aspect of data analysis for medical stakeholders to frame decision strategies and to design routine set-ups. PCA is old mathematical machine learning grouping analysis technique but popular in recently for data analysis in grouping insights, so the researcher has implemented principal component analysis to study dominance in data with varied component grouping with proportional variation and also used graphical visualizations. The strength of PCA implementation is to maintain real valued data with dimension reduction but without loss of key information. The experiment result of COVID-19 datais showing component 1 contributing to highly positive testResult that is having High impact on patients. PCA shows relative dimensions analysis. PCA dimensions plotted shows independence in dimension with 900 angle dimensions in data spread. The results identified for COVID-19 data glimpse with dominant component formation.
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In concentrating photovoltaic (CPV), increasing the incoming sunlight to the solar cell influences the performance of the solar cells. The optical efficiency of the CPV components is a key factor to improve the electrical efficien...
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In concentrating photovoltaic (CPV), increasing the incoming sunlight to the solar cell influences the performance of the solar cells. The optical efficiency of the CPV components is a key factor to improve the electrical efficiency. Two types of homogeniser materials (K9 glass and crystal resin) were investigated in the CPV application. The results show a higher power generation of the CPV module when using K9 glass homogeniser compared to the crystal resin homogeniser by 27% due to the high transmittance value of the K9 glass material. In addition, the K9 glass material shows an excellent resistance to the heat produced by the concentrated sunlight compared to the crystal resin material. (C) 2019 Elsevier B.V. All rights reserved.
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The Ag/PTCDA/PEDOT:PSS/p-Si Schottky diode has been fabricated by adding a layer of organic compound 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA) on top of the p-Si for which the junction characteristics have been investi...
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The Ag/PTCDA/PEDOT:PSS/p-Si Schottky diode has been fabricated by adding a layer of organic compound 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA) on top of the p-Si for which the junction characteristics have been investigated. The electronic properties of the device have been studied by the conventional I-V and the Norde's methods. For conventional I-V measurements the rectifying behavior has been observed with a rectification ratio of 236. The barrier height and ideality factor values of 0.81 eV and 3.5, respectively, for the structure have been obtained from the forward bias I-V characteristics. Various electrical parameters such as reverse saturation current, series resistance and shunt resistance have been calculated from the analysis of experimental I-V results and discussed in detail. The barrier height and the series resistance determined by the Norde's function are found in good agreement with the values calculated from conventional I-V measurements. The charge conduction mechanism has also been discussed.
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Проведены эксперименты по мечению пирацетама технецием-99m. В оптимальных условиях (pH 6, восстановитель SnCl_2·2H_2O, комнатная темп...
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Проведены эксперименты по мечению пирацетама технецием-99m. В оптимальных условиях (pH 6, восстановитель SnCl_2·2H_2O, комнатная температура, 30 мин) достигнут радиохимический выход 97%. Опыты по биораспределению in vivo показали, что начальное накопление в мозгу хорошо коррелирует со сродством соединения к мозгу. Накопление ~(99m)Tc-пирацeтама в мозгу составило 6, 12.3, 5.3 и 3.3%/г ткани через 5, 30, 60 и 120 мин после инъекции соответственно. ~(99m)Tc-пирацeтам перспективен в радиорецепторном анализе на содержание нейролептических лекарств и для визуализации мозга.
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As large amounts of porcine cartilage are discarded as waste in daily life, it is necessary to find new uses for them. We extracted polysaccharide from cartilage and performed in vitro and in vivo experiments in cancer cells. A mo...
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As large amounts of porcine cartilage are discarded as waste in daily life, it is necessary to find new uses for them. We extracted polysaccharide from cartilage and performed in vitro and in vivo experiments in cancer cells. A mouse breast-cancer pulmonary metastasis model was set up, and we tried to determine the mechanism of the inhibition of metastasis by cartilage PS (polysaccharide). Effects on tumour size and the progression of metastasis indicated that cartilage PS can obviously inhibit metastasis in breast-cancer cells. The levels of LNR I (laminin receptor I), αvβ3 integrin and MMP-9 (matrix metalloproteinase-9) in mice treated or not with cartilage PS showed significant differences. Cartilage PS inhibited the growth of MCF-7 human breast adenocarcinoma cells, but had little effect on normal cells. Cartilage PS can inhibit the activity of the MMP-2 and the MMP-9 by decreasing the levels of LNRI and αvβ3 integrin to inhibit metastasis further. In summary, we conclude that cartilage PS can act as a specific anti-metastatic agent in breast-cancer cells.
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4-(3-(thiophen-2-yl)-9H-carbazol-9-yl) benzaldehyde (TPCBZ) was synthesized under microwave irradiation with auto generated pressure (at 130.0 degrees C) and characterized by H-1 NMR, C-13 NMR, Mass and FTIR spectroscopy, thin-lay...
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4-(3-(thiophen-2-yl)-9H-carbazol-9-yl) benzaldehyde (TPCBZ) was synthesized under microwave irradiation with auto generated pressure (at 130.0 degrees C) and characterized by H-1 NMR, C-13 NMR, Mass and FTIR spectroscopy, thin-layer chromatography (TLC), and elemental analyses. Here, a thin-layer of TPCBZ onto glassy carbon electrode (GCE) is fabricated with conducting coating agents (5% nafion) to fabricate a selective and selective Cu2+ sensor in short response time in phosphate buffer phase. The fabricated sensor (TPCBZ/Nafion/GCE) is exhibited higher sensitivity, large-dynamic concentration ranges, long-term stability, and improved electrochemical performances towards TPCBZ-conjugated copper complex for selective Cu2+ sensor. The calibration plot is linear (r(2): 0.9979) over the large Cu2+ ions concentration ranges (1.0 nMe1.0 mM). The sensitivity and detection limit is similar to 1.12974 mu Acm(-2) mu M-1 and similar to 0.84 +/- 0.02 nM (signal-to-noise ratio, at a SNR of 3) respectively, which is calculated from the slope of the calibration plot. This novel effort is initiated a well-organize way of efficient cationic sensor improvement with carbazide for heavy metallic pollutants in environmental and health-care fields in large scales. (C) 2016 Elsevier B.V. All rights reserved.
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